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dc.contributor.authorFelipe, Maria Sueli Soares-
dc.contributor.authorAndrade, Rosângela Vieira de-
dc.contributor.authorArraes, Fabrício Barbosa Monteiro-
dc.contributor.authorNicola, André Moraes-
dc.contributor.authorMaranhão, Andréa Queiroz-
dc.contributor.authorTorres, Fernando Araripe Gonçalves-
dc.contributor.authorPereira, Ildinete Silva-
dc.contributor.authorFonseca, Márcio José Poças-
dc.contributor.authorCampos, Élida Geralda-
dc.contributor.authorMoraes, Lídia Maria Pepe de-
dc.contributor.authorAndrade, Patrícia Albuquerque de-
dc.contributor.authorTavares, Aldo Henrique Fonseca Pacheco-
dc.contributor.authorSilva, Simoneide Souza-
dc.contributor.authorKyaw, Cynthia Maria-
dc.contributor.authorSouza, Diorge Paulo-
dc.contributor.authorPbGenome Network-
dc.contributor.authorPereira, Maristela-
dc.contributor.authorJesuíno, Rosália Santos Amorim-
dc.contributor.authorAndrade, Edmar Vaz de-
dc.contributor.authorParente, Juliana Alves-
dc.contributor.authorOliveira, Gisele Silva de-
dc.contributor.authorBarbosa, Mônica Santiago-
dc.contributor.authorMartins, Natália Florêncio-
dc.contributor.authorFachin, Ana Lúcia-
dc.contributor.authorCardoso, Renato Sousa-
dc.contributor.authorPassos Júnior, Geraldo Aleixo da Silva-
dc.contributor.authorAlmeida Júnior, Nalvo Franco de-
dc.contributor.authorWalter, Maria Emília Machado Telles-
dc.contributor.authorSoares, Célia Maria de Almeida-
dc.contributor.authorCarvalho, Maria José Albuquerque de-
dc.contributor.authorBrígido, Marcelo de Macedo-
dc.date.accessioned2013-03-07T12:10:38Z-
dc.date.available2013-03-07T12:10:38Z-
dc.date.issued2005-07-
dc.identifier.citationFELIPE, Maria Sueli Soares et al. Transcriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cells. The Journal Of Biological Chemistry, Rockville, v. 280, n. 26, Issue of July 1, p. 24706–24714, 2005. Disponível em: <http://www.jbc.org/content/280/26/24706.full.pdf>. Acesso em: 07 mar. 2013. DOI 10.1074/jbc.M500625200en
dc.identifier.urihttp://repositorio.unb.br/handle/10482/12393-
dc.descriptionThis work was supported by MCT, CNPq, CAPES, FUB, UFG, and FUNDECT-MS. PbGenome Network: Alda Maria T. Ferreira, Alessandra Dantas, Alessandra J. Baptista, Alexandre M. Bailão, Ana Lídia Bonato, André C. Amaral, Bruno S. Daher, Camila M. Silva, Christiane S. Costa, Clayton L. Borges, Cléber O. Soares, Cristina M. Junta, Daniel A. S. Anjos, Edans F. O. Sandes, Eduardo A. Donadi, Elza T. Sakamoto-Hojo, Flábio R. Araújo, Flávia C. Albuquerque, Gina C. Oliveira, João Ricardo M. Almeida, Juliana C. Oliveira, Kláudia G. Jorge, Larissa Fernandes, Lorena S. Derengowski, Luís Artur M. Bataus, Marcus A. M. Araújo, Marcus K. Inoue, Marlene T. De-Souza, Mauro F. Almeida, Nádia S. Parachin, Nadya S. Castro, Odair P. Martins, Patrícia L. N. Costa, Paula Sandrin-Garcia, Renata B. A. Soares, Stephano S. Mello, and Viviane C. B. Reisen
dc.description.abstractParacoccidioides brasiliensis is the causative agent of paracoccidioidomycosis, a disease that affects 10 million individuals in Latin America. This report depicts the results of the analysis of 6,022 assembled groups from mycelium and yeast phase expressed sequence tags, covering about 80% of the estimated genome of this dimorphic, thermo-regulated fungus. The data provide a comprehensive view of the fungal metabolism, including overexpressed transcripts, stage-specific genes, and also those that are up- or down-regulated as assessed by in silico electronic subtraction and cDNA microarrays. Also, a significant differential expression pattern in mycelium and yeast cells was detected, which was confirmed by Northern blot analysis, providing insights into differential metabolic adaptations. The overall transcriptome analysis provided information about sequences related to the cell cycle, stress response, drug resistance, and signal transduction pathways of the pathogen. Novel P. brasiliensis genes have been identified, probably corresponding to proteins that should be addressed as virulence factor candidates and potential new drug targets.en
dc.language.isoInglêsen
dc.publisherSociedade Americana de Bioquímica e Biologia Molecular-
dc.rightsAcesso Abertoen
dc.titleTranscriptional profiles of the human pathogenic fungus paracoccidioides brasiliensis in mycelium and yeast cellsen
dc.typeArtigoen
dc.subject.keywordParacoccidioides brasiliensisen
dc.subject.keywordFungos patogênicosen
dc.subject.keywordMicologiaen
dc.rights.licensePermitido copiar, distribuir, transmitir e adaptar a obra - sem nenhum custo e sem permissão - para uso não comercial, desde que citada a fonte original. "This research was originally published in The Journal of Biological Chemistry. Maria Sueli S. Felipe, Rosângela V. Andrade, Fabrício B. M. Arraes, André M. Nicola, Andrea Q. Maranhão, Fernando A. G. Torres, Ildinete Silva-Pereira, Márcio J. Poças-Fonseca, Élida G. Campos,a Lídia M. P. Moraes,a Patrícia A. Andrade,Aldo H. F. P. Tavares, Simoneide S. Silva, Cynthia M. Kyaw,a Diorge P. Souza,PbGenome Network, Maristela Pereira,a Rosália S. A. Jesuíno, Edmar V. Andrade,Juliana A. Parente, Gisele S. Oliveira, Mônica S. Barbosa, Natália F. Martins, Ana L. Fachin, Renato S. Cardoso, Geraldo A. S. Passos, Nalvo F. Almeida, Maria Emília M. T. Walter,Célia M. A. Soares,Maria José A. Carvalho and Marcelo M. Brígido. Transcriptional Profiles of the Human Pathogenic Fungus Paracoccidioides brasiliensis in Mycelium and Yeast Cells. The Journal of Biological Chemistry. 2005, Vol. 280, No. 26, Issue of July 1, pp. 24706–24714. © Sociedade Americana de Bioquímica e Biologia Molecular." Fonte: http://www.jbc.org/site/misc/Copyright_Permission.xhtml. Acesso em: 07 mar. 2013.en
dc.identifier.doiDOI https://dx.doi.org/10.1074/jbc.M500625200en
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