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dc.contributor.authorJaramillo, Natalia Gil-
dc.contributor.authorMotta, Flávia Nader-
dc.contributor.authorFavali, Cecilia Beatriz Fiuza-
dc.contributor.authorBastos, Izabela Marques Dourado-
dc.contributor.authorSantana, Jaime Martins de-
dc.date.accessioned2017-07-25T17:41:00Z-
dc.date.available2017-07-25T17:41:00Z-
dc.date.issued2016-07-14-
dc.identifier.citationJARAMILLO, Natalia Gil et al. Dendritic cells: a double-edged sword in immune responses during chagas disease. Frontiers in Microbiology, v. 7, Article 107, 14 jul. 2016. Disponível em: <http://journal.frontiersin.org/article/10.3389/fmicb.2016.01076/full>. Acesso em: 21 jun. 2017. doi: http://journal.frontiersin.org/article/10.3389/fmicb.2016.01076/full.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/23883-
dc.language.isoInglêspt_BR
dc.publisherFrontierspt_BR
dc.rightsAcesso Abertopt_BR
dc.titleDendritic cells : a double-edged sword in immune responses during chagas diseasept_BR
dc.typeArtigopt_BR
dc.subject.keywordCélulas dendríticaspt_BR
dc.subject.keywordAntígenospt_BR
dc.subject.keywordTrypanosoma cruzipt_BR
dc.subject.keywordChagas, Doença dept_BR
dc.rights.licenseCopyright©2016Gil-Jaramillo,Motta,Favali,BastosandSantana.Thisisan open-accessarticledistributedunderthetermsofthe Creative Commons Attribution License (CCBY). Theuse,distributionorreproductioninotherforumsispermitted, providedtheoriginalauthor(s)orlicensorarecreditedandthattheoriginal publicationinthisjournaliscited,inaccordancewithacceptedacademicpractice. No use,distributionorreproductionispermittedwhichdoesnotcomplywiththese terms.pt_BR
dc.identifier.doihttps://dx.doi.org/10.3389/fmicb.2016.01076pt_BR
dc.description.abstract1Dendritic cells (DCs) are the most important member of the antigen presenting cells group due to their ability to recognize antigen at the infection site and their high specialized antigen internalization capacity. These cells have central role in connecting the innate and adaptive immune responses against Trypanosoma cruzi, the causative agent of Chagas disease. These first line defense cells modulate host immune response depending on type, maturation level, cytokine milieu and DC receptor involved in the interactions with T. cruzi, influencing the development of the disease clinic forms. Here, we present a review of DCs–T. cruzi interactions both in human and murine models, pointing out the parasite ability to manipulate DCs activity for the purpose of evading innate immune response and assuring its own survival and persistence.pt_BR
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