| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Oliveira, S. C. | - |
| dc.contributor.author | Harms, J. S. | - |
| dc.contributor.author | Rech, E. L. | - |
| dc.contributor.author | Rodarte, Renato Santos | - |
| dc.contributor.author | Bocca, Anamélia Lorenzetti | - |
| dc.contributor.author | Goes, A. M. | - |
| dc.contributor.author | Splitter, G. A. | - |
| dc.date.accessioned | 2017-08-23T14:49:47Z | - |
| dc.date.available | 2017-08-23T14:49:47Z | - |
| dc.date.issued | 1998-01 | - |
| dc.identifier.citation | OLIVEIRA, S. C. et al. The role of T cell subsets and cytokines in the regulation of intracellular bacterial infection. Brazilian Journal of Medical and Biological Research, v. 31, n. 1, p. 77-84, jan. 1998. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100010>. Acesso em: 10 jul 2017. doi: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100010. | pt_BR |
| dc.identifier.uri | http://repositorio.unb.br/handle/10482/24248 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | Associação Brasileira de Divulgação Científica | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | The role of T cell subsets and cytokines in the regulation of intracellular bacterial infection | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Imunologia veterinária | pt_BR |
| dc.subject.keyword | Bacterioses | pt_BR |
| dc.subject.keyword | Brucelose | pt_BR |
| dc.subject.keyword | Citocinas | pt_BR |
| dc.rights.license | Brazilian Journal of Medical and Biological Research - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License (Attribution 4.0 International (CC BY 4.0)). Fonte: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100010>. Acesso em: 10 jul 2017. | pt_BR |
| dc.identifier.doi | https://dx.doi.org/10.1590/S0100-879X1998000100010 | pt_BR |
| dc.description.abstract1 | Cellular immune responses are a critical part of the host's defense against intracellular bacterial infections. Immunity to Brucella abortus crucially depends on antigen-specific T cell-mediated activation of macrophages, which are the major effectors of cell-mediated killing of this organism. T lymphocytes that proliferate in response to B. abortus were characterized for phenotype and cytokine activity. Human, murine, and bovine T lymphocytes exhibited a type 1 cytokine profile, suggesting an analogous immune response in these different hosts. In vivo protection afforded by a particular cell type is dependent on the antigen presented and the mechanism of antigen presentation. Studies using MHC class I and class II knockout mice infected with B. abortus have demonstrated that protective immunity to brucellosis is especially dependent on CD8+ T cells. To target MHC class I presentation we transfected ex vivo a murine macrophage cell line with B. abortus genes and adoptively transferred them to BALB/c mice. These transgenic macrophage clones induced partial protection in mice against experimental brucellosis. Knowing the cells required for protection, vaccines can be designed to activate the protective T cell subset. Lastly, as a new strategy for priming a specific class I-restricted T cell response in vivo, we used genetic immunization by particle bombardment-mediated gene transfer. | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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