Skip navigation
Use este identificador para citar ou linkar para este item: http://repositorio.unb.br/handle/10482/24560
Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
ARTIGO_ClinicalComplicationsG6PD.pdf967,89 kBAdobe PDFVisualizar/Abrir
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorMonteiro, Wuelton Marcelo-
dc.contributor.authorFranca, Gabriel Peixoto-
dc.contributor.authorMelo, Gisely Cardoso de-
dc.contributor.authorQueiroz, Amanda de Lourdes Maciel-
dc.contributor.authorBrito, Marcelo-
dc.contributor.authorPeixoto, Henry Maia-
dc.contributor.authorOliveira, Maria Regina Fernandes de-
dc.contributor.authorRomero, Gustavo Adolfo Sierra-
dc.contributor.authorBassat, Quique-
dc.contributor.authorLacerda, Marcus Vinícius Guimarães de-
dc.date.accessioned2017-09-18T15:21:14Z-
dc.date.available2017-09-18T15:21:14Z-
dc.date.issued2014-02-25-
dc.identifier.citationMONTEIRO, Wuelton Marcelo et al. Clinical complications of G6PD deficiency in Latin American and Caribbean populations: systematic review and implications for malaria elimination programmes. Malaria Journal, v. 13, article 70, 25 fev. 2014. Disponível em: <https://malariajournal.biomedcentral.com/articles/10.1186/1475-2875-13-70>. Acesso em: 11 jul. 2017. doi: https://doi.org/10.1186/1475-2875-13-70.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/24560-
dc.language.isoInglêspt_BR
dc.publisherBioMed Centralpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleClinical complications of G6PD deficiency in Latin American and Caribbean populations : systematic review and implications for malaria elimination programmespt_BR
dc.typeArtigopt_BR
dc.subject.keywordGlicosefosfato desidrogenasept_BR
dc.subject.keywordAnemia hemolíticapt_BR
dc.subject.keywordMaláriapt_BR
dc.subject.keywordMedicamentospt_BR
dc.rights.license© 2014 Monteiro et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.pt_BR
dc.identifier.doihttps://dx.doi.org/10.1186/1475-2875-13-70pt_BR
dc.description.abstract1Background: Although G6PDd individuals are generally asymptomatic throughout their life, the clinical burden of this genetic condition includes a range of haematological conditions, including acute haemolytic anaemia (AHA), neonatal jaundice (NNJ) and chronic non-sphaerocytic anaemia (CNSA). In Latin America (LA), the huge knowledge gap regarding G6PDd is related to the scarce understanding of the burden of clinical manifestation underlying G6PDd carriage. The aim of this work was to study the clinical significance of G6PDd in LA and the Caribbean region through a systematic review. Methods: A systematic search of the published literature was undertaken in August 2013. Bibliographies of manuscripts were also searched and additional references were identified. Only original research was included. All study designs were included, as long as any clinical information was present. Studies were eligible for inclusion if they reported clinical information from populations living in LA or Caribbean countries or about migrants from these countries living in countries outside this continent. Results: The Medline search generated 487 papers, and the LILACS search identified 140 papers. After applying the inclusion criteria, 100 original papers with any clinical information on G6PDd in LA were retrieved. Additionally, 16 articles were included after reading the references from these papers. These 116 articles reported data from 18 LA and Caribbean countries. The major clinical manifestations reported from LA countries were those related to AHA, namely drug-induced haemolysis. Most of the published works regarding drug-induced haemolysis in LA referred to haemolytic crises in P. vivax malaria patients during the course of the treatment with primaquine (PQ). Favism, infection-induced haemolysis, NNJ and CNSA appear to play only a minor public health role in this continent. Conclusion: Haemolysis in patients using PQ seems to be the major clinical manifestation of G6PDd in LA and contributes to the morbidity of P. vivax infection in this continent, although the low number of reported cases, which could be linked to under-reporting of complications. These results support the need for better strategies to diagnose and manage G6PDd in malaria field conditions. Additionally, Malaria Control Programmes in LA should not overlook this condition in their national guidelines.pt_BR
dc.description.unidadeFaculdade de Medicina (FMD)-
Aparece nas coleções:Artigos publicados em periódicos e afins

Mostrar registro simples do item Visualizar estatísticas



Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.