Título:	Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil
Autor(es):	Wolff, Vanessa Lucena Vasconcelos, Pedro F. C. Silva, Eliana Vieira Pinto Santos, João Barberino
Assunto:	Febre amarela - Goiás (Estado) Vacinas Luziânia (GO)
Data de publicação:	Abr-2013
Editora:	Sociedade Brasileira de Medicina Tropical - SBMT
Referência:	MACHADO, Vanessa Wolff et al. Serologic assessment of yellow fever immunity in the rural population of a yellow fever-endemic area in Central Brazil. Revista da Sociedade Brasileira de Medicina Tropical, Uberaba, v. 46, n. 2, p. 166-171, mar./abr. 2013. DOI: http://dx.doi.org/10.1590/0037-8682-0007-2012. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000200166&lng=en&nrm=iso. Acesso em: 04 dez. 2020.
Abstract:	Introduction: The yellow fever epidemic that occurred in 1972/73 in Central Brazil surprised the majority of the population unprotected. A clinical-epidemiological survey conducted at that time in the rural area of 19 municipalities found that the highest (13.8%) number of disease cases were present in the municipality of Luziânia, State of Goiás. Methods: Thirty-eight years later, a new seroepidemiological survey was conducted with the aim of assessing the degree of immune protection of the rural population of Luziânia, following the continuous attempts of public health services to obtain vaccination coverage in the region. A total of 383 volunteers, aged between 5 and 89 years and with predominant rural labor activities (75.5%), were interviewed. The presence of antibodies against the yellow fever was also investigated in these individuals, by using plaque reduction neutralization test, and correlated to information regarding residency, occupation, epidemiological data and immunity against the yellow fever virus. Results: We found a high (97.6%) frequency of protective titers (>1:10) of neutralizing antibodies against the yellow fever virus; the frequency of titers of 1:640 or higher was 23.2%, indicating wide immune protection against the disease in the study population. The presence of protective immunity was correlated to increasing age. Conclusions: This study reinforces the importance of surveys to address the immune state of a population at risk for yellow fever infection and to the surveillance of actions to control the disease in endemic areas.
Unidade Acadêmica:	Faculdade de Medicina (FMD)
Licença:	Revista da Sociedade Brasileira de Medicina Tropical - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY NC 3.0). Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000200166&lng=en&tlng=en. Acesso em: 04 dez. 2020.
DOI:	https://dx.doi.org/10.1590/0037-8682-0007-2012
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