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dc.contributor.authorMonteiro, Wuelton Marcelopt_BR
dc.contributor.authorVal, Fernando Fonseca de Almeidapt_BR
dc.contributor.authorSiqueira, André Machadopt_BR
dc.contributor.authorFranca, Gabriel Peixotopt_BR
dc.contributor.authorSampaio, Vanderson de Souzapt_BR
dc.contributor.authorMelo, Gisely Cardoso dept_BR
dc.contributor.authorAlmeida, Anne Cristine Gomes dept_BR
dc.contributor.authorBrito, Marcelopt_BR
dc.contributor.authorPeixoto, Henry Maiapt_BR
dc.contributor.authorFuller, Douglaspt_BR
dc.contributor.authorBassat, Quiquept_BR
dc.contributor.authorRomero, Gustavo Adolfo Sierrapt_BR
dc.contributor.authorOliveira, Maria Regina Fernandes dept_BR
dc.contributor.authorLacerda, Marcus Vinícius Guimarães dept_BR
dc.date.accessioned2017-12-07T05:07:03Z-
dc.date.available2017-12-07T05:07:03Z-
dc.date.issued2014pt_BR
dc.identifier.citationMONTEIRO, Wuelton Marcelo et al. G6PD deficiency in Latin America: systematic review on prevalence and variants. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 109, n. 5, p. 553-568, ago. 2014. DOI: http://dx.doi.org/10.1590/0074-0276140123. Disponível em: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500553&lng=en&tlng=en. Acesso em: 21 jul. 2020.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/29137-
dc.language.isoenpt_BR
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúdept_BR
dc.rightsAcesso Abertopt_BR
dc.titleG6PD deficiency in Latin America : systematic review on prevalence and variantspt_BR
dc.typeArtigopt_BR
dc.subject.keywordGlicosefosfato desidrogenasept_BR
dc.subject.keywordMaláriapt_BR
dc.subject.keywordPlasmodium vivaxpt_BR
dc.subject.keywordMedicamentospt_BR
dc.subject.keywordHemólisept_BR
dc.subject.keywordIndígenaspt_BR
dc.rights.licenseMemórias do Instituto Oswaldo Cruz - (CC BY-NC) - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500553&lng=en&tln g=en. Acesso em: 21 jul. 2020.-
dc.identifier.doihttps://dx.doi.org/10.1590/0074-0276140123pt_BR
dc.description.abstract1Plasmodium vivax radical cure requires the use of primaquine (PQ), a drug that induces haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals, which further hampers malaria control efforts. The aim of this work was to study the G6PDd prevalence and variants in Latin America (LA) and the Caribbean region. A systematic search of the published literature was undertaken in August 2013. Bibliographies of manuscripts were also searched and additional references were identified. Low prevalence rates of G6PDd were documented in Argentina, Bolivia, Mexico, Peru and Uruguay, but studies from Curaçao, Ecuador, Jamaica, Saint Lucia, Suriname and Trinidad, as well as some surveys carried out in areas of Brazil, Colombia and Cuba, have shown a high prevalence (> 10%) of G6PDd. The G6PD A-202A mutation was the variant most broadly distributed across LA and was identified in 81.1% of the deficient individuals surveyed. G6PDd is a frequent phenomenon in LA, although certain Amerindian populations may not be affected, suggesting that PQ could be safely used in these specific populations. Population-wide use of PQ as part of malaria elimination strategies in LA cannot be supported unless a rapid, accurate and field-deployable G6PDd diagnostic test is made available.-
dc.description.unidadeFaculdade de Medicina (FMD)-
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