Título:	Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats
Autor(es):	Sousa, Dircilei Nascimento de Santana, Washington Macedo de Ferreira, Vania Maria Moraes Duarte, Wagner Rodrigues
Assunto:	Cognição Comportamento Sinvastatina Ossos - regeneração Ratos
Data de publicação:	2014
Editora:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Referência:	SOUSA, Dircilei Nascimento de et al. Behavioural and cognitive effects of simvastatin dose used in stimulation of bone regeneration in rats. Acta Cirurgica Brasileira, São Paulo, v. 29, n. 3, p. 151-157, mar. 2014. DOI: http://dx.doi.org/10.1590/S0102-86502014000300002. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000300151&lng=en&nrm=iso. Acesso em: 26 nov. 2019.
Abstract:	PURPOSE: To analyze the effects of simvastatin (SVT) in the locomotion, anxiety and memory of rats, as a reflection of the administration of a minimum dose capable of stimulating bone regeneration in defects in the calvariae.METHODS: Surgical procedures were performed in 15 female Wistar rats, 2-month old, to insert the grafting material regenerator (Bone-ceramic(r)) and/or SVT, followed by behavioural and cognitive assessments in the 7th, 30th and 60th days post surgery.RESULTS: The SVT locally applied with the goal of bone regeneration in defects created in rat calvariae does not interfere with locomotion, anxiety levels and/or memories of rats, except for the first week following surgery, when an anxiolytic effect was observed, as a result of a possible central action.CONCLUSION: Failure to provoke any response within 30 and 60 days post surgical procedures suggests that SVT may constitute a good choice in stimulating bone regeneration without affecting the long term neural functions.
Licença:	Acta Cirurgica Brasileira - (CC BY NC) - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502014000300151&lng=en&tlng=en. Acesso em: 26 nov. 2019.
DOI:	https://dx.doi.org/10.1590/S0102-86502014000300002
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