Título:	The effect of simvastatin on relapse of tooth movement and bone mineral density in rats measured by a new method using microtomography
Autor(es):	Vieira, Giovanni Modesto Chaves, Sacha Braun Ferreira, Vânia Maria Moraes Freitas, Karina Maria Salvatore de Amorim, Rivadávio Fernandes Batista de
Assunto:	Sinvastatina Microtomografia Rato Densitometria óssea
Data de publicação:	Mai-2015
Editora:	Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Referência:	VIEIRA, Giovanni Modesto et al. The effect of simvastatin on relapse of tooth movement and bone mineral density in rats measured by a new method using microtomography. Acta Cirurgica Brasileira, São Paulo, v. 30, n. 5, p. 319-327, maio 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000500319&lng=en&nrm=iso>. Acesso em: 17 abr. 2018. doi: http://dx.doi.org/10.1590/S0102-865020150050000003.
Abstract:	Purpose: to evaluate the effect of simvastatin on relapse of tooth movement in rats using microtomography (micro CT), as well as the correlation of bone density with the orthodontic relapse. Methods: twenty-five adult male Wistar rats, divided into two groups, had stainless steel springs installed on left maxillary first molar. The molars were moved for 18 days, and after removing the springs, were applied by oral gavage, 5mg/kg of simvastatin in the experimental group for 20 days. Tooth relapse was assessed with a micro CT scanner, and the images chosen through the Data Viewer software 1.5.0.0 had their measurement guides made and checked by the software Image ProR plus 5.1, and compared by Mann-Whitney test. After rats were sacrificed, bone mineral density was evaluated by micro CT through the software CT Analyzer 1.13 and compared by independent T-test, as well as by Spearman correlation test. Results: relapse and bone mineral density (BMD) was lower in the experimental group than in the control group, however without a statistically significant difference. Conclusion: simvastatin did not inhibit the relapse of tooth movement in rats, and there was no correlation between bone density and orthodontic relapse.
Unidade Acadêmica:	Faculdade de Medicina (FMD)
Licença:	Acta Cirurgica Brasileira - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY NC 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000500319&lng=en&nrm=iso. Acesso em: 17 abr. 2018.
DOI:	http://dx.doi.org/10.1590/S0102-865020150050000003
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