Skip navigation
Use este identificador para citar ou linkar para este item: http://repositorio.unb.br/handle/10482/29983
Arquivos associados a este item:
Arquivo TamanhoFormato 
ARTIGO_ThyroidHormoneReceptor.pdf579,71 kBAdobe PDFVisualizar/Abrir
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorGonçalves, Alexandrept_BR
dc.contributor.authorTolentino, Chineyder Corrêapt_BR
dc.contributor.authorSouza, Fernanda Rodrigues dept_BR
dc.contributor.authorHuss, Juliana Carla da Costapt_BR
dc.contributor.authorZinato, Karolinne de Lourdespt_BR
dc.contributor.authorLopes, Leandro Teixeira Paranhospt_BR
dc.contributor.authorFurlanetto Júnior, Robertopt_BR
dc.contributor.authorNeves, Francisco de Assis Rochapt_BR
dc.date.accessioned2017-12-07T05:14:15Z-
dc.date.available2017-12-07T05:14:15Z-
dc.date.issued2015-04pt_BR
dc.identifier.citationGONÇALVES, Alexandre et al. The thyroid hormone receptor β-selective agonist GC-1 does not affect tolerance to exercise in hypothyroid rats. Archives of Endocrinology and Metabolism, São Paulo, v. 59, n. 2, p. 141-147, abr. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000200141&lng=en&nrm=iso>. Acesso em: 16 mar. 2018. doi: http://dx.doi.org/10.1590/2359-3997000000027.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/29983-
dc.language.isoenpt_BR
dc.publisherSociedade Brasileira de Endocrinologia e Metabologiapt_BR
dc.rightsAcesso Abertopt_BR
dc.titleThe thyroid hormone receptor β-selective agonist GC-1 does not affect tolerance to exercise in hypothyroid ratspt_BR
dc.typeArtigopt_BR
dc.subject.keywordExercícios físicospt_BR
dc.subject.keywordTireóidept_BR
dc.subject.keywordHipotiroidismopt_BR
dc.rights.licenseArchives of Endocrinology and Metabolism - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY NC 3.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972015000200141&lng=en&nrm=iso. Acesso em: 16 mar. 2018.-
dc.identifier.doihttp://dx.doi.org/10.1590/2359-3997000000027pt_BR
dc.description.abstract1Objective: investigate the effect of GC-1 on tolerance to exercise in rats with experimental hypothyroidism. Materials and methods: hypothyroidism was induced with methimazole sodium and perchlorate treatment. Six groups with eight animals were studied: control group (C), hypothyroid group without treatment (HYPO); hypothyroidism treated with physiological doses of tetraiodothyronine (T4) or 10 times higher (10×T4); hypothyroidism treated with equal molar doses of GC-1 (GC-1) or 10 times higher (10×GC-1). After eight weeks, each animal underwent an exercise tolerance test by measuring the time (seconds), in which the rats were swimming with a load attached to their tails without being submerging for more than 10 sec. After the test, the animals were killed, and blood samples were collected for biochemical analysis, and the heart and soleus muscle were removed for weighing and morphometric analysis of the cardiomyocyte. Results: hypothyroidism significantly reduced tolerance to exercise and, treatment with GC-1 1× or T4 in physiological doses recover tolerance test to normal parameters. However, high doses of T4 also decreased tolerance to physical exercise. Conversely, ten times higher doses of GC-1 did not impair tolerance to exercise. Interestingly, hypothyroidism, treated or not with T4 in a physiological range, GC-1 or even high doses of GC-1 (10X) did not change cardiomyocyte diameters and relative weight of the soleus muscle. In contrast, higher doses of T4 significantly increased cardiomyocyte diameter and induced atrophy of the soleus muscle. Conclusion: unlike T4, GC-1 in high doses did not modify tolerance to physical exercise in the rats with hypothyroidism.-
Aparece nas coleções:Artigos publicados em periódicos e afins

Mostrar registro simples do item Visualizar estatísticas



Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.