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dc.contributor.authorMachado, Márcio Carlospt_BR
dc.contributor.authorFragoso, Maria Candida Barisson Vilarespt_BR
dc.contributor.authorMoreira, Ayrton Custódiopt_BR
dc.contributor.authorBoguszewski, César Luizpt_BR
dc.contributor.authorVieira Neto, Leonardopt_BR
dc.contributor.authorNaves, Luciana Ansanelipt_BR
dc.contributor.authorVilar, Luciopt_BR
dc.contributor.authorAraújo, Luiz Antônio dept_BR
dc.contributor.authorCzepielewski, Mauro Antoniopt_BR
dc.contributor.authorGadelha, Monica R.pt_BR
dc.contributor.authorMusolino, Nina Rosa Castropt_BR
dc.contributor.authorMiranda, Paulo Augusto Carvalhopt_BR
dc.contributor.authorBronstein, Marcello Delanopt_BR
dc.contributor.authorOliveira Júnior, Antônio Ribeiropt_BR
dc.date.accessioned2017-12-07T05:19:37Z-
dc.date.available2017-12-07T05:19:37Z-
dc.date.issued2016-06pt_BR
dc.identifier.citationMACHADO, Márcio Carlos et al. Recommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazil. Archives of Endocrinology and Metabolism, São Paulo, v. 60, n. 3, p. 267-286, jun. 2016. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300267&lng=en&nrm=iso>. Acesso em: 11 dez. 2017. doi: http://dx.doi.org/10.1590/2359-3997000000174.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/30496-
dc.language.isoenpt_BR
dc.publisherSociedade Brasileira de Endocrinologia e Metabologiapt_BR
dc.rightsAcesso Abertopt_BR
dc.titleRecommendations of the neuroendocrinology department of the Brazilian society of endocrinology and metabolism for the diagnosis of Cushing’s disease in Brazilpt_BR
dc.typeArtigopt_BR
dc.subject.keywordCushing, Doença de - diagnósticopt_BR
dc.subject.keywordSíndrome de Cushingpt_BR
dc.rights.licenseArchives of Endocrinology and Metabolism - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972016000300267&lng=en&nrm=iso. Acesso em: 11 dez. 2017.-
dc.identifier.doihttp://dx.doi.org/10.1590/2359-3997000000174pt_BR
dc.description.abstract1Although it is a rare condition, the accurate diagnosis and treatment of Cushing’s disease is important due to its higher morbidity and mortality compared to the general population, which is attributed to cardiovascular diseases, diabetes mellitus and infections. Screening for hypercortisolism is recommended for patients who present multiple and progressive clinical signs and symptoms, especially those who are considered to be more specific to Cushing’s syndrome, abnormal findings relative to age (e.g., spinal osteoporosis and high blood pressure in young patients), weight gain associated with reduced growth rate in the pediatric population and for those with adrenal incidentalomas. Routine screening is not recommended for other groups of patients, such as those with obesity or diabetes mellitus. Magnetic resonance imaging (MRI) of the pituitary, the corticotropin-releasing hormone (CRH) test and the high-dose dexamethasone suppression test are the main tests for the differential diagnosis of ACTH-dependent Cushing’s syndrome. Bilateral and simultaneous petrosal sinus sampling is the gold standard method and is performed when the triad of initial tests is inconclusive, doubtful or conflicting. The aim of this article is to provide information on the early detection and establishment of a proper diagnosis of Cushing’s disease, recommending follow-up of these patients at experienced referral centers.-
dc.description.unidadeFaculdade de Medicina (FMD)-
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