Título:	The potential use of melatonin for preventing cisplatin ototoxicity : an insight for a clinical approach
Autor(es):	Araujo, Juliana Gusmão de Sampaio, André Luiz Lopes Venosa, Alessandra Ramos Oliveira, Carlos Augusto Costa Pires de
Assunto:	Melatonina Prevenção Tratamento Agentes antineoplásicos Ototoxicidade
Data de publicação:	Ago-2014
Editora:	Hindawi
Referência:	ARAUJO, Juliana Gusmão de et al. The potential use of melatonin for preventing cisplatin ototoxicity: an insight for a clinical approach. Advances in Otolaryngology, Londres, v. 2014, Article ID 185617, p. 1-8, ago. 2014. Disponível em: <https://www.hindawi.com/archive/2014/185617/>. Acesso em: 7 dez. 2017. doi: http://dx.doi.org/10.1155/2014/185617.
Abstract:	Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited by its serious side effects, such as nephrotoxicity and ototoxicity. Ototoxicity produced by cisplatin is usually persistent, depending on the age of the patient, the cumulative number of doses, the number of chemotherapy cycles, the history of noise exposure, and deteriorating renal function. The mechanism of the ototoxicity caused by cisplatin is based on the generation of reactive oxygen species, which interfere with the antioxidant protection of the organ of Corti. Thus, protecting the cochlea with antioxidants ameliorates ototoxicity from cisplatin. In this context, melatonin appears as a therapeutic option for preventing the ototoxic effects of cisplatin, since the research in the last decade has proven its ability to be both a direct free radical scavenger and indirect antioxidant. In this sense, some of the evidence suggesting that melatonin is efficient for combating cisplatin-induced ototoxicity is summarized and discussed in this paper.
Unidade Acadêmica:	Faculdade de Medicina (FMD)
Licença:	Copyright © 2014 Juliana Gusmão de Araujo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: https://www.hindawi.com/archive/2014/185617/. Acesso em: 7 dez. 2017.
DOI:	http://dx.doi.org/10.1155/2014/185617
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