Título:	Dietary carotenoid-rich oil supplementation improves exercise-induced anisocytosis in runners : influences of haptoglobin, MnSOD (Val9Ala), CAT (21A/T) and GPX1 (Pro198Leu) gene polymorphisms in dilutional pseudoanemia ("sports anemia")
Autor(es):	Vilela, Ana Luísa Miranda Akimoto, Arthur Kenji Alves, Penha Cristina Zaidan Pereira, Luiz Carlos da Silva Guimarães, Maria de Nazaré Klautau Grisolia, Cesar Koppe
Assunto:	Pequi Sangue - exame Antioxidantes
Data de publicação:	Mar-2010
Editora:	Sociedade Brasileira de Genética
Referência:	MIRANDA-VILELA, Ana L. et al. Dietary carotenoid-rich oil supplementation improves exercise-induced anisocytosis in runners: influences of haptoglobin, MnSOD (Val9Ala), CAT (21A/T) and GPX1 (Pro198Leu) gene polymorphisms in dilutional pseudoanemia ("sports anemia"). Genetics and Molecular Biology, São Paulo, v. 33, n. 2, p. 359-367, mar. 2010. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200026&lng=en&nrm=iso>. Acesso em: 24 out. 2017. doi: http://dx.doi.org/10.1590/S1415-47572010005000022.
Abstract:	Physical training induces beneficial adaptation, whereas exhaustive exercises increase reactive oxygen-species generation, thereby causing oxidative damage in plasma and erythrocytes, fractions susceptible to lipid peroxidation. Pequi (Caryocar brasiliense Camb.) is a Brazilian Cerrado fruit containing a carotenoid-rich oil. The aim was to investigate the effects of pequi-oil on exercise-induced oxidative damage in plasma and erythrocytes, after running in the same environment and undergoing weekly training under the same conditions as to type, intensity and length. Evaluations were accomplished after outdoor running on flat land before and after ingestion of 400 mg pequi-oil capsules for 14 days. Blood samples were taken after running and submitted to TBARS assay and erythrogram analysis. Haptoglobin, MnSOD (Val9Ala), CAT (21A/T) and GPX1 (Pro198Leu) gene polymorphisms were priorly investigated, so as to estimate genetic influence The reduction in erythrocytes, hemoglobin and hematocrit after pequi-oil treatment was notably associated with higher plasma expansion. Except for MCHC (mean corpuscular hemoglobin concentration) and RDW (red cell distribution width), the results were influenced by the polymorphisms studied. The best response to pequi-oil was presented by MnSOD Val/Val, CAT AA or AT genotypes and the GPX1 Pro allele. The significantly lower RDW and higher MHCH values were related to pequi-oil protective effects. Pequi oil, besides possessing other nutritional properties, showed protective blood effects.
Licença:	Genetics and Molecular Biology - All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. (CC BY NC). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572010000200026&lng=en&nrm=iso. Acesso em: 24 out. 2017.
DOI:	http://dx.doi.org/10.1590/S1415-47572010005000022
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