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dc.contributor.authorMachado, Márcio Carlospt_BR
dc.contributor.authorFragoso, Maria Candida Barisson Vilarespt_BR
dc.contributor.authorMoreira, Ayrton Custódiopt_BR
dc.contributor.authorBoguszewski, César Luizpt_BR
dc.contributor.authorVieira Neto, Leonardopt_BR
dc.contributor.authorNaves, Luciana Ansanelipt_BR
dc.contributor.authorVilar, Luciopt_BR
dc.contributor.authorAraújo, Luiz Antônio dept_BR
dc.contributor.authorMusolino, Nina Rosa Castropt_BR
dc.contributor.authorMiranda, Paulo Augusto C.pt_BR
dc.contributor.authorCzepielewski, Mauro Antoniopt_BR
dc.contributor.authorGadelha, Monica R.pt_BR
dc.contributor.authorBronstein, Marcello Delanopt_BR
dc.contributor.authorRibeiro-Oliveira Jr., Antôniopt_BR
dc.date.accessioned2019-01-02T13:57:50Z-
dc.date.available2019-01-02T13:57:50Z-
dc.date.issued2018pt_BR
dc.identifier.citationMACHADO, Márcio Carlos et al. A review of Cushing's disease treatment by the Department of Neuroendocrinology of the Brazilian Society of Endocrinology and Metabolism. Archives of Endocrinology and Metabolism, São Paulo, v. 62, n. 1, p. 87-105, fev. 2018. DOI: http://dx.doi.org/10.20945/2359-3997000000014. Disponível em: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000100087&lng=en&nrm=iso. Acesso em: 21 fev. 2019.pt_BR
dc.identifier.urihttp://repositorio.unb.br/handle/10482/33728-
dc.language.isoenpt_BR
dc.publisherSociedade Brasileira de Endocrinologia e Metabologiapt_BR
dc.rightsAcesso Abertopt_BR
dc.titleA review of Cushing's disease treatment by the Department of Neuroendocrinology of the Brazilian Society of Endocrinology and Metabolismpt_BR
dc.typeArtigopt_BR
dc.subject.keywordCushing, Doença dept_BR
dc.subject.keywordSíndrome de Cushingpt_BR
dc.rights.license(CC BY) - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972018000100087&lng=en&nrm=iso. Acesso em: 21 fev. 2019.-
dc.identifier.doihttp://dx.doi.org/10.20945/2359-3997000000014pt_BR
dc.description.abstract1The treatment objectives for a patient with Cushing's disease (CD) are remission of hypercortisolism, adequate management of co-morbidities, restoration of the hypothalamic-pituitary-adrenal axis, preservation of fertility and pituitary function, and improvement of visual defects in cases of macroadenomas with suprasellar extension. Transsphenoidal pituitary surgery is the main treatment option for the majority of cases, even in macroadenomas with low probability of remission. In cases of surgical failure, another subsequent pituitary surgery might be indicated in cases with persistent tumor imaging at post surgical magnetic resonance imaging (MRI) and/or pathology analysis of adrenocorticotropic hormone-positive (ACTH+) positive pituitary adenoma in the first procedure. Medical treatment, radiotherapy and adrenalectomy are the other options when transsphenoidal pituitary surgery fails. There are several options of medical treatment, although cabergoline and ketoconazole are the most commonly used alone or in combination. Novel treatments are also addressed in this review. Different therapeutic approaches are frequently needed on an individual basis, both before and, particularly, after surgery, and they should be individualized. The objective of the present review is to provide the necessary information to achieve a more effective treatment for CD. It is recommended that patients with CD be followed at tertiary care centers with experience in treating this condition.-
dc.description.unidadeFaculdade de Medicina (FMD)-
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