Título:	Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surfacefunctionalization
Autor(es):	Félix, L. León Sanz, B. Sebastián, V. Torres, T. E. Sousa, Marcelo Henrique Huamaní Coaquira, José Antonio Ibarra, M. R. Goya, G. F.
ORCID:	https://orcid.org/0000-0002-6116-9331 https://orcid.org/0000-0003-1210-8329 https://orcid.org/0000-0003-1558-9279
Assunto:	Nanopartículas Magnetismo Calor - efeito fisiológico
Data de publicação:	Mar-2019
Editora:	Nature
Referência:	FÉLIX, L. Léon et al. Gold-decorated magnetic nanoparticles design for hyperthermia applications and as a potential platform for their surfacefunctionalization. Scientific Reports, v. 9, art. 4185, mar. 2019. DOI: https://doi.org/10.1038/s41598-019-40769-2. Disponível em: https://www.nature.com/articles/s41598-019-40769-2. Acesso em: 18 nov. 2019.
Abstract:	The integration of noble metal and magnetic nanoparticles with controlled structures that can couple various specific effects to the different nanocomposite in multifunctional nanosystems have been found interesting in the field of medicine. In this work, we show synthesis route to prepare small Au nanoparticles of sizes <d> = 3.9 ± 0.2 nm attached to Fe3O4 nanoparticle cores (<d> = 49.2 ± 3.5 nm) in aqueous medium for potential application as a nano-heater. Remarkably, the resulted Au decorated PEI-Fe3O4 (Au@PEI-Fe3O4) nanoparticles are able to retain bulk magnetic moment MS = 82–84 Am2/ kgFe3O4, with the Verwey transition observed at TV = 98 K. In addition, the in vitro cytotoxicity analysis of the nanosystem microglial BV2 cells showed high viability (>97.5%) to concentrate up to 100 μg/mL in comparison to the control samples. In vitro heating experiments on microglial BV2 cells under an ac magnetic field (H0 = 23.87 kA/m; f = 571 kHz) yielded specific power absorption (SPA) values of SPA = 43 ± 3 and 49 ± 1 μW/cell for PEI-Fe3O4 and Au@PEI-Fe3O4 NPs, respectively. These similar intracellular SPA values imply that functionalization of the magnetic particles with Au did not change the heating efficiency, providing at the same time a more flexible platform for multifunctional functionalization.
Licença:	Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
DOI:	https://doi.org/10.1038/s41598-019-40769-2
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