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Use este identificador para citar ou linkar para este item: http://repositorio.unb.br/handle/10482/35910
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dc.contributor.authorCarneiro, Fabiana Pirani-
dc.contributor.authorMuniz‑Junqueira, Maria Imaculada-
dc.contributor.authorCarneiro, Marcos de Vasconcelos-
dc.contributor.authorOliveira, Ísis de Araújo-
dc.contributor.authorSoares, Aluízio Carlos-
dc.contributor.authorHaar, Nathália de Vargas-
dc.contributor.authorTakano, Gustavo Henrique Soares-
dc.contributor.authorVianna, Leonora Maciel de Sousa-
dc.contributor.authorCaldas, Guilherme de Carvalho-
dc.contributor.authorVieira, Danillo Leal Marinho-
dc.contributor.authorFrutuoso, Lígia Lins-
dc.contributor.authorBrito, Larissa Matos Rodrigues-
dc.contributor.authorSiqueira, Rafael Vieira Martins de-
dc.contributor.authorParente, Amanda Moreira-
dc.contributor.authorCastro, Tercia Maria Mendes Lousa de-
dc.contributor.authorPeres, Isabela-
dc.contributor.authorMendes, Lianna Martha Soares-
dc.contributor.authorBorges, Tatiana Karla dos Santos-
dc.contributor.authorFerreira, Vânia Moraes-
dc.contributor.authorMotoyama, Andrea Barretto-
dc.date.accessioned2019-12-02T14:39:44Z-
dc.date.available2019-12-02T14:39:44Z-
dc.date.issued2019-
dc.identifier.citationCARNEIRO, Fabiana Pirani et al. Anti‑EpCAM antibodies for detection of metastatic carcinoma in effusions and peritoneal wash. Oncology y Letters, v. 18, p. 2019-2024, 2019. DOI: 10.3892/ol.2019.10468. Disponível em: https://www.spandidos-publications.com/10.3892/ol.2019.10468/abstract. Acesso em: 02 dez. 2019.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/35910-
dc.language.isoInglêspt_BR
dc.publisherSpandidos Publicationspt_BR
dc.rightsAcesso Restritopt_BR
dc.titleAnti‑EpCAM antibodies for detection of metastatic carcinoma in effusions and peritoneal washpt_BR
dc.typeArtigopt_BR
dc.subject.keywordCâncerpt_BR
dc.subject.keywordAnticorpospt_BR
dc.subject.keywordImunocitoquímicapt_BR
dc.subject.keywordDerramept_BR
dc.identifier.doi10.3892/ol.2019.10468pt_BR
dc.relation.publisherversionhttps://www.spandidos-publications.com/10.3892/ol.2019.10468/abstractpt_BR
dc.description.abstract1Epithelial cell adhesion molecule (EpCAM) has been used as diagnostic/prognostic marker and therapeutic target. The aim of the present study was to compare immunoreactivity of antibodies against distinct epitopes in the ectodomain of EpCAM for detection of carcinoma from different primary sites and of different histological types in effusions and peritoneal wash. Two antibodies against epitopes in the EGF‑like domain I (clones Moc‑31 and Ber‑EP4) and one antibody against the epitope in the cysteine‑poor region (158210) of EpCAM were used (all commercially available). Independently of the clone used, EpCAM overexpression was observed in almost all samples when all the adenocarcinoma samples were analyzed together. By using Moc‑31, EpCAM overexpression was observed in all samples of adenocarcinoma. Absence of EpCAM overexpression was observed in a few adenocarcinoma samples at some sites of tumor origin, including ovary, breast and stomach, when Ber‑EP4 and 158210 were used. Regarding carcinomas aside from adenocarcinomas, histological types, such as squamous cell, urothelial and small cell carcinoma showed different degrees of EpCAM expression according to the antibody used. In squamous cell carcinoma, overexpression was observed only with the clone 158210. It was concluded that, overall, most samples of metastatic carcinoma from effusions showed overexpression of EpCAM. However, there are significant variations in its detection according to the primary site, histological type of the carcinoma and depending on the antibody used. Thus, the use of more than one type of anti‑EpCAM antibody would increase the chance of its detection in metastatic carcinoma effusion.pt_BR
dc.rights.holderCopyright © 2019, Spandidos Publications-
dc.description.unidadeFaculdade de Medicina (FM)-
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