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dc.contributor.authorNeves, Juliete Silva-
dc.contributor.authorSilva, Zita Lopes da-
dc.contributor.authorBrito Neta, Maria de Sousa-
dc.contributor.authorChaves, Sacha Braun-
dc.contributor.authorNóbrega, Yanna Karla de Medeiros-
dc.contributor.authorMachado, Angelo Henrique de Lira-
dc.contributor.authorSilva, Fabricio Machado-
dc.date.accessioned2019-12-05T14:25:13Z-
dc.date.available2019-12-05T14:25:13Z-
dc.date.issued2019-07-
dc.identifier.citationNEVES, Juliete Silva et al. Preparation of terpolymer capsules containing Rosmarinus officinalis essential oil and evaluation of its antifungal activity. RSC Advances, v. 9, 22586, 2019. DOI: 10.1039/c9ra02336d. Disponível em: https://pubs.rsc.org/en/content/articlelanding/2019/ra/c9ra02336d#!divAbstract. Acesso em: 05 dez. 2019.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/35912-
dc.language.isoInglêspt_BR
dc.publisherThe Royal Society of Chemistrypt_BR
dc.rightsAcesso Abertopt_BR
dc.titlePreparation of terpolymer capsules containing Rosmarinus officinalis essential oil and evaluation of its antifungal activitypt_BR
dc.typeArtigopt_BR
dc.subject.keywordAlecrimpt_BR
dc.subject.keywordEssências e óleos essenciaispt_BR
dc.subject.keywordCápsulas (Farmácia)pt_BR
dc.subject.keywordAntimicóticospt_BR
dc.rights.license(CC BY NC) - This article is licensed under Creative Commons Attribution-NonCommercial 3.0 Unported Licence.pt_BR
dc.identifier.doi10.1039/c9ra02336dpt_BR
dc.description.abstract1The essential oil from Rosmarinus officinalis presents antifungal activity and is used in industry as a natural preserving agent. However, essential oils are unstable compounds. So, the encapsulation of essential oils is a technique used to protect it, minimizing degradation and reducing undesired interaction with the other formulation components. Thus, this work focuses on the synthesis of terpolymeric capsules containing essential oil from Rosmarinus officinalis, aiming to use it as an antifungal component in cosmetics. The capsules were obtained via terpolymerization of methyl methacrylate, styrene and methacrylic acid in a dispersed phase polymerization process. The properties of the polymers and the fungicide activity were evaluated. The studied essential oil presented a Minimum Inhibitory Concentration (MIC) ranging from 2.25 to 4.5 mg mL 1 and a Minimum Fungicidal Concentration (MFC) from 4.5 to 9.0 mg mL 1 for strains of Candida albicans, Candida glabrata and Candida parapsilosis, and after the encapsulation process, the antifungal activity of the oil was maintained. Additionally, cytotoxicity assays against fibroblast cell lines and human keratinocytes showed that the polymeric nanocapsules containing Rosmarinus officinalis essential oil can be regarded as a very promising material intended for cosmetics and drug delivery applications.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4284-9929pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3041-1906pt_BR
dc.description.unidadeInstituto de Química (IQ)pt_BR
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