Production of gallocyanine nanogel as drug delivery system for tauopathies

Lunardi, Claure Nain; Siqueira, F. S.; Leal, F. F.; Siqueira, J. W. S.; Souza, Igor A. de; Gomes, Anderson de Jesus

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Campo DC	Valor	Idioma
dc.contributor.author	Lunardi, Claure Nain	-
dc.contributor.author	Siqueira, F. S.	-
dc.contributor.author	Leal, F. F.	-
dc.contributor.author	Siqueira, J. W. S.	-
dc.contributor.author	Souza, Igor A. de	-
dc.contributor.author	Gomes, Anderson de Jesus	-
dc.date.accessioned	2019-12-10T13:59:32Z	-
dc.date.available	2019-12-10T13:59:32Z	-
dc.date.issued	2018	-
dc.identifier.citation	Claure Nain Lunardi et al. Production of gallocyanine nanogel as drug delivery system for tauopathies. Journal of Nanomaterials & Molecular Nanotechnology, v. 7, p. 48, 2018. DOI: 10.4172/2324-8777-C3-027.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/35925	-
dc.description	Trabalho apresentado na International Conference on Materials Science & Engineering, Roma, Itália, 25-26 jun. 2018.	pt_BR
dc.language.iso	Inglês	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.title	Production of gallocyanine nanogel as drug delivery system for tauopathies	pt_BR
dc.type	Artigo	pt_BR
dc.identifier.doi	10.4172/2324-8777-C3-027	pt_BR
dc.description.abstract1	The aim of this study was to develop and characterize nanogels loaded with gallocyanine dye (GC) for controlled delivery. This dye is as an inhibitor of DKK1-LRP5/6 interactions (Remelli , Zheng and Wu ). Phenoxazines are compounds, present in several bioactive molecules and natural products that display diverse biological activities. Importantly, phenothiazine compounds have also been reported to able to activate the Wnt signaling pathway as indicated by the increased levels of β-catenin, and decrease the DKK1-induced Tau phosphorylation at serine 396 (Thysiadis et al.) The controlled delivery of drugs may be accomplished by employing various polymeric drug carriers such as natural polymers. The great advantage using chitosan polymers are the low cost and biocompatibility ability to entrapments of diverse drugs. The development and characterization of GC-nanogel such as size, zeta potential, drug release in different pH’s and SEM images were obtained for this preparation. GC-nanogel may be a promising vehicle for the drug delivery to inhibit DKK1 in neurodegenerative tauopathies. FAPDF, CNPq, CAPES, FINATEC.	pt_BR
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