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dc.contributor.authorNóbrega, Yanna Karla de Medeiros-
dc.date.accessioned2020-02-18T17:21:16Z-
dc.date.available2020-02-18T17:21:16Z-
dc.date.issued2018-
dc.identifier.citationNÓBREGA, Yanna Karla de Medeiros. Genotype DQ2.5/DQ2.2 (𝛽2/𝛽2) and high celiac disease risk development. In: RODRIGO, Luis; HERNÁNDEZ-LAHOZ, Carlos (ed.). Celiac disease: from the bench to the clinic. Londres: IntechOpen, 2018.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/36925-
dc.language.isoInglêspt_BR
dc.publisherIntechOpenpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleGenotype DQ2.5/DQ2.2 (𝛽2/𝛽2) and high celiac disease risk developmentpt_BR
dc.typeParte de livro ou capítulo de livropt_BR
dc.subject.keywordDoença celíacapt_BR
dc.subject.keywordFatores de riscopt_BR
dc.rights.license© 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY)pt_BR
dc.description.abstract1Celiac disease (CD) is a genetically determined immune-mediated disorder in which gluten immunogenic peptides are presented to CD4 T cells by HLA-DQ2.5, DQ8, DQ2.2, and their combinations. CD is considered one of the most wellcharacterized autoimmune diseases, having a described environmental factor, a well-established pathogenesis, associated genetic factors, and a well-established laboratory diagnosis, although it is still considered a difficult-to-classify disease. In the last decades, advances in laboratory diagnosis with the emergence of molecular biology techniques have allowed a specific characterization of the CD-associated genotypes and, although clinically the disease management was not modified by this factor, the follow-up of patients at risk of CD development has greatly benefited from the possibility of specifically finding the inherited genotype, and whether it represents a greater or lesser risk for developing the disease. In some populations, it is already possible to calculate the exact risk associated to the inherited genome by each individual, but the genotypes available in several countries sometimes disregard the relevance of searching beyond the genotypes DQ2.5/ DQ2.5, DQ2.5/DQ8, and DQ2.5/DQ2.2, which also present a high risk for developing the disease.pt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
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