| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Santos, Beatriz Werneck Lopes | - |
| dc.contributor.author | Oliveira, Regina Célia de | - |
| dc.contributor.author | Oliveira, Julia Sonsin | - |
| dc.contributor.author | Fagg, Christopher William | - |
| dc.contributor.author | Barbosa, José Beethoven Figueiredo | - |
| dc.contributor.author | Caldas, Eloisa Dutra | - |
| dc.date.accessioned | 2020-07-24T19:42:33Z | - |
| dc.date.available | 2020-07-24T19:42:33Z | - |
| dc.date.issued | 2020-07-09 | - |
| dc.identifier.citation | SANTOS, Beatriz Werneck Lopes et al. Biodiversity of β-carboline profile of banisteriopsis caapi and ayahuasca, a plant and a brew with neuropharmacological potential. Plants, v. 9, n. 7, 870. DOI: https://doi.org/10.3390/plants9070870. Disponível em: https://www.mdpi.com/2223-7747/9/7/870. Acesso em: 24 jul. 2020. | pt_BR |
| dc.identifier.uri | https://repositorio.unb.br/handle/10482/39296 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | MDPI | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Biodiversity of β-carboline profile of banisteriopsis caapi and ayahuasca, a plant and a brew with neuropharmacological potential | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Betacarbolina | pt_BR |
| dc.subject.keyword | Cipó-mariri | pt_BR |
| dc.subject.keyword | Ayahuasca | pt_BR |
| dc.rights.license | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution
(CC BY) license (http://creativecommons.org/licenses/by/4.0/). | - |
| dc.identifier.doi | https://doi.org/10.3390/plants9070870 | pt_BR |
| dc.description.abstract1 | Ayahuasca is a psychoactive infusion with a large pharmacological application normally
prepared with Banisteriopsis caapi, which contains the monoamine oxidase inhibitors β-carbolines,
and Psichotria virids, which contains the serotonin receptor agonist N,N dimethyltryptamine (DMT).
The objectives of this study were to investigate the chemical profile of B. caapi and of ayahuasca collected
in various Brazilian regions. In total, 176 plant lianas, of which 159 B. caapi and 33 ayahuasca samples
were analyzed. Dried liana samples were powdered, extracted with methanol, diluted, and analyzed
by LC-MS/MS. Ayahuasca samples were diluted and analyzed. Mean concentrations in B. caapi were
4.79 mg/g harmine, 0.451 mg/g harmaline, and 2.18 mg/g tetrahydroharmine (THH), with a high
variability among the samples (RSD from 78.9 to 170%). Native B. caapi samples showed significantly
higher harmine concentrations than cultivated ones, and samples from the Federal District/Goiás had
higher THH content than those collected in the State of Acre. The other Malpighiaceae samples did
not contain β-carbolines, except for one D. pubipetala sample. Concentrations in ayahuasca samples
ranged from 0.109 to 7.11 mg/mL harmine, 0.012 to 0.945 mg/mL harmaline, 0.09 to 3.05 mg/mL THH,
and 0.10 to 3.12 mg/mL DMT. The analysis of paired ayahuasca/B. caapi confirmed that harmine is
reduced to harmaline and to THH during the brew preparation. This is the largest study conducted
with Malpighiaceae samples and showed a large variability in the main β-carbolines present in B. caapi.
This biodiversity is a challenge for standardization of the material used in ethnopharmacological
studies of B. caapi and ayahuasca. | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0003-0486-3690 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0001-7891-2630 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-4905-8145 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0001-6072-7832 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-7197-6807 | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
|
