| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Melo, Heloísa Antoniella Braz de | - |
| dc.contributor.author | Nascimento, Gabriel Pasquarelli do | - |
| dc.contributor.author | Corrêa, Rafael | - |
| dc.contributor.author | Almeida, Raquel das Neves | - |
| dc.contributor.author | Santos, Igor de Oliveira | - |
| dc.contributor.author | Prado, Paulo Sousa | - |
| dc.contributor.author | Picolo, Victor | - |
| dc.contributor.author | Bem, Andreza Fabro de | - |
| dc.contributor.author | Pizato, Nathalia Marcolini Pelucio | - |
| dc.contributor.author | Magalhães, Kelly Grace | - |
| dc.date.accessioned | 2020-11-11T14:40:25Z | - |
| dc.date.available | 2020-11-11T14:40:25Z | - |
| dc.date.issued | 2019-12-27 | - |
| dc.identifier.citation | MELO, Heloísa Antoniella Braz de et al. Potential neuroprotective and antiinfammatory efects provided by omega-3 (DHA) against Zika virus infection in human SH-SY5Y cells. Scientific Reports, v. 9, 20119, 2019. DOI: https://doi.org/10.1038/s41598-019-56556-y. Disponível em: https://www.nature.com/articles/s41598-019-56556-y. Acesso em: 11 nov. 2020. | pt_BR |
| dc.identifier.uri | https://repositorio.unb.br/handle/10482/39623 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | Nature Research | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Potential neuroprotective and antiinfammatory efects provided by omega-3 (DHA) against Zika virus infection in human SH-SY5Y cells | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Ômega 3 | pt_BR |
| dc.subject.keyword | Zika vírus | pt_BR |
| dc.rights.license | (CC BY) - Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2019 | pt_BR |
| dc.identifier.doi | https://doi.org/10.1038/s41598-019-56556-y | pt_BR |
| dc.description.abstract1 | Zika virus (ZIKV) has a strong tropism for the nervous system and has been related to post-infection
neurological syndromes. Once neuronal cells are infected, the virus is capable of modulating cell
metabolism, leading to neurotoxicity and cellular death. The negative efect of ZIKV in neuron cells has
been characterized. However, the description of molecules capable of reversing these cytotoxic efects
is still under investigation. In this context, it has been largely demonstrated that docosahexaenoic
acid (DHA), an omega-3 polyunsaturated fatty acid, is highly neuroprotective. Here, we hypothesized
that DHA’s neuroprotective proprieties could have an infuence on ZIKV-induced neurotoxicity in SHSY5Y cells. Our data showed that pre-treatment of SH-SY5Y cells with DHA increased the cell viability
and proliferation in ZIKV-infected cells. Moreover, DHA triggered an anti-infammatory response in
those infected cells. Besides, DHA was capable of restoring mitochondria function and number in ZIKVinfected SH-SY5Y cells. In addition, cells pre-treated with DHA prior to ZIKV infection presented a lower
viral load at diferent times of infection. Taking together, these results demonstrated that DHA has a
potential anti-infammatory and neuroprotective efect against ZIKV infection in these neuron-like cells
and could be a useful tool in the treatment against this virus. | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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