| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Mayer, Andréia Biolchi | - |
| dc.contributor.author | Oliveira, Danilo Gustavo Rodrigues de | - |
| dc.contributor.author | Amaral, Henrique de Oliveira | - |
| dc.contributor.author | Campos, Gabriel Avohay Alves | - |
| dc.contributor.author | Gonçalves, Jacqueline Coimbra | - |
| dc.contributor.author | Souza, Adolfo Carlos Barros de | - |
| dc.contributor.author | Lima, Marcos Robalinho | - |
| dc.contributor.author | Silva, Luciano Paulino | - |
| dc.contributor.author | Mortari, Márcia Renata | - |
| dc.date.accessioned | 2020-11-11T18:28:52Z | - |
| dc.date.available | 2020-11-11T18:28:52Z | - |
| dc.date.issued | 2020-08-27 | - |
| dc.identifier.citation | BIOLCH, Andréia Mayer et al. Fraternine, a novel wasp peptide, protects against motor impairments in 6-OHDA model of Parkinsonism. Toxins, v. 12, n. 9, 550, 2020. DOI: https://doi.org/10.3390/toxins12090550. Disponível em: https://www.mdpi.com/2072-6651/12/9/550. Acesso em: 11 nov. 2020. | pt_BR |
| dc.identifier.uri | https://repositorio.unb.br/handle/10482/39625 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | MDPI | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Fraternine, a novel wasp peptide, protects against motor impairments in 6-OHDA model of Parkinsonism | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Vespa - veneno | pt_BR |
| dc.subject.keyword | Capacidade motora | pt_BR |
| dc.subject.keyword | Parkinson, Doença de | pt_BR |
| dc.rights.license | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | pt_BR |
| dc.identifier.doi | https://doi.org/10.3390/toxins12090550 | pt_BR |
| dc.description.abstract1 | Parkinson’s disease (PD) is a progressive neurodegenerative condition that affects the
Central Nervous System (CNS). Insect venoms show high molecular variability and selectivity in
the CNS of mammals and present potential for the development of new drugs for the treatment
of PD. In this study, we isolated and identified a component of the venom of the social wasp
Parachartergus fraternus and evaluated its neuroprotective activity in the murine model of PD. For this
purpose, the venom was filtered and separated through HPLC; fractions were analyzed through mass
spectrometry and the active fraction was identified as a novel peptide, called Fraternine. We performed
two behavioral tests to evaluate motor discoordination, as well as an apomorphine-induced rotation
test. We also conducted an immunohistochemical assay to assess protection in TH+ neurons in the
Substantia Nigra (SN) region. Group treated with 10 µg/animal of Fraternine remained longer in the
rotarod compared to the lesioned group. In the apomorphine test, Fraternine decreased the number
of rotations between treatments. This dose also inhibited dopaminergic neuronal loss, as indicated
by immunohistochemical analysis. This study identified a novel peptide able to prevent the death
of dopaminergic neurons of the SN and recover motor deficit in a 6-OHDA-induced murine model
of PD. | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-5901-0911 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0001-9075-7725 | pt_BR |
| dc.description.unidade | Faculdade de Medicina (FMD) | - |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
|
