ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19

Zipeto, Donato; Palmeira, Julys da Fonseca; Argañaraz, Gustavo Adolfo; Argañaraz, Enrique Roberto

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Campo DC	Valor	Idioma
dc.contributor.author	Zipeto, Donato	-
dc.contributor.author	Palmeira, Julys da Fonseca	-
dc.contributor.author	Argañaraz, Gustavo Adolfo	-
dc.contributor.author	Argañaraz, Enrique Roberto	-
dc.date.accessioned	2020-11-16T20:09:53Z	-
dc.date.available	2020-11-16T20:09:53Z	-
dc.date.issued	2020-10-07	-
dc.identifier.citation	ZIPETO, Donato et al. ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19. Frontiers in Immunology, v. 11, art. 576745, out. 2020. DOI: https://doi.org/10.3389/fimmu.2020.576745. Disponível em: https://www.frontiersin.org/articles/10.3389/fimmu.2020.576745/full. Acesso em: 16 nov. 2020.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/39636	-
dc.language.iso	Inglês	pt_BR
dc.publisher	Frontiers	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.title	ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	ADAM17	pt_BR
dc.subject.keyword	ACE2	pt_BR
dc.subject.keyword	TMPRSS2	pt_BR
dc.subject.keyword	SARS-CoV-2	pt_BR
dc.subject.keyword	Covid-19	pt_BR
dc.rights.license	Copyright © 2020 Zipeto, Palmeira, Argañaraz and Argañaraz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.	pt_BR
dc.identifier.doi	https://doi.org/10.3389/fimmu.2020.576745	pt_BR
dc.description.abstract1	The Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and chronic lung disease have been identified as the main COVID-19 comorbidities. Moreover, despite similar infection rates between men and women, the most severe course of the disease is higher in elderly and co-morbid male patients. Therefore, the occurrence of specific comorbidities associated with renin–angiotensin system (RAS) imbalance mediated by the interaction between angiotensin-converting enzyme 2 (ACE2) and desintegrin and metalloproteinase domain 17 (ADAM17), along with specific genetic factors mainly associated with type II transmembrane serine protease (TMPRSS2) expression, could be decisive for the clinical outcome of COVID-19. Indeed, the exacerbated ADAM17—mediated ACE2, TNF-α, and IL-6R secretion emerges as a possible underlying mechanism for the acute inflammatory immune response and the activation of the coagulation cascade. Therefore, in this review, we focus on the main pathophysiological aspects of ACE2, ADAM17, and TMPRSS2 host proteins in COVID-19. Additionally, we discuss a possible mechanism to explain the deleterious effect of ADAM17 and TMPRSS2 over-activation in the COVID-19 outcome.	pt_BR
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