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dc.contributor.authorFideles, Lázaro de Sousa-
dc.contributor.authorMiranda, João Antônio Leal de-
dc.contributor.authorMartins, Conceição da Silva-
dc.contributor.authorBarbosa, Maria Lucianny Lima-
dc.contributor.authorPimenta, Helder Bindá-
dc.contributor.authorPimentel, Paulo Vitor de Souza-
dc.contributor.authorTeixeira, Claudio Silva-
dc.contributor.authorScafuri, Marina Alves Sampaio-
dc.contributor.authorFaçanha, Samuel de Osterno-
dc.contributor.authorBarreto, João Erivan Façanha-
dc.contributor.authorCarvalho, Poliana Moreira de Medeiros-
dc.contributor.authorScafuri, Ariel Gustavo-
dc.contributor.authorAraújo, Joabe Lima-
dc.contributor.authorRocha, Jefferson Almeida-
dc.contributor.authorVieira, Icaro Gusmão Pinto-
dc.contributor.authorRicardo, Nágila Maria Pontes Silva-
dc.contributor.authorCampelo, Matheus da Silva-
dc.contributor.authorRibeiro, Maria Elenir Nobre Pinho-
dc.contributor.authorBrito, Gerly Anne de Castro-
dc.contributor.authorCerqueira, Gilberto Santos-
dc.date.accessioned2021-01-15T19:12:27Z-
dc.date.available2021-01-15T19:12:27Z-
dc.date.issued2020-06-17-
dc.identifier.citationFIDELES, Lázaro de Sousa et al. Role of rutin in 5-Fluorouracil-induced intestinal mucositis: prevention of histological damage and reduction of inflammation and oxidative stress. Molecules, v. 25, n. 12, 2786, 2020. DOI: https://doi.org/10.3390/molecules25122786. Disponível em: https://www.mdpi.com/1420-3049/25/12/2786. Acesso em: 15 jan. 2021.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/39919-
dc.language.isoInglêspt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleRole of rutin in 5-Fluorouracil-induced intestinal mucositis : prevention of histological damage and reduction of inflammation and oxidative stresspt_BR
dc.typeArtigopt_BR
dc.subject.keywordFlavonóidespt_BR
dc.subject.keywordInflamaçãopt_BR
dc.subject.keywordIntestinospt_BR
dc.rights.license© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/molecules25122786pt_BR
dc.description.abstract1Intestinal mucositis, characterized by inflammatory and/or ulcerative processes in the gastrointestinal tract, occurs due to cellular and tissue damage following treatment with 5-fluorouracil (5-FU). Rutin (RUT), a natural flavonoid extracted from Dimorphandra gardneriana, exhibits antioxidant, anti-inflammatory, cytoprotective, and gastroprotective properties. However, the effect of RUT on inflammatory processes in the intestine, especially on mucositis promoted by antineoplastic agents, has not yet been reported. In this study, we investigated the role of RUT on 5-FU-induced experimental intestinal mucositis. Swiss mice were randomly divided into seven groups: Saline, 5-FU, RUT-50, RUT-100, RUT-200, Celecoxib (CLX), and CLX + RUT-200 groups. The mice were weighed daily. After treatment, the animals were euthanized and segments of the small intestine were collected to evaluate histopathological alterations (morphometric analysis); malondialdehyde (MDA), myeloperoxidase (MPO), and glutathione (GSH) concentrations; mast and goblet cell counts; and cyclooxygenase-2 (COX-2) activity, as well as to perform immunohistochemical analyses. RUT treatment (200 mg/kg) prevented 5-FU-induced histopathological changes and reduced oxidative stress by decreasing MDA concentrations and increasing GSH concentrations. RUT attenuated the inflammatory response by decreasing MPO activity, intestinal mastocytosis, and COX-2 expression. These results suggest that the COX-2 pathway is one of the underlying protective mechanisms of RUT against 5-FU-induced intestinal mucositis.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0273-4169pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1652-6544pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1863-5701pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4806-9192pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-1849-5403pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-0286-1974pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6896-7179pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8214-4379pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6717-3772pt_BR
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