| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Sousa Neto, Ivo Vieira de | - |
| dc.contributor.author | Durigan, João Luiz Quagliotti | - |
| dc.contributor.author | Farias Junior, Gonçalo Carreiro de | - |
| dc.contributor.author | Bogni, Fabio Henrique | - |
| dc.contributor.author | Ruivo, Amanda Lima | - |
| dc.contributor.author | Araújo, Juliana Oliveira de | - |
| dc.contributor.author | Nonaka, Keico Okino | - |
| dc.contributor.author | Selistre-de-Araújo, Heloísa | - |
| dc.contributor.author | Marqueti, Rita de Cássia | - |
| dc.date.accessioned | 2021-02-19T14:06:32Z | - |
| dc.date.available | 2021-02-19T14:06:32Z | - |
| dc.date.issued | 2021-01-08 | - |
| dc.identifier.citation | SOUSA NETO, Ivo Vieira de et al. Resistance training modulates the matrix mtalloproteinase-2 activity in different trabecular bones in aged rats. Clinical Interventions in Aging, v. 16, p. 71-81, 8 jan. 2021. DOI https://doi.org/10.2147/CIA.S276518. Disponível em: https://www.dovepress.com/resistance-training-modulates-the-matrix-metalloproteinase-2-activity--peer-reviewed-article-CIA. Acesso em: 19 fev. 2021 | pt_BR |
| dc.identifier.uri | https://repositorio.unb.br/handle/10482/40093 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | Dove Press | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Resistance training modulates the matrix mtalloproteinase-2 activity in different trabecular bones in aged rats | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Envelhecimento | pt_BR |
| dc.subject.keyword | Sistema musculoesquelético | pt_BR |
| dc.subject.keyword | Remodelação | pt_BR |
| dc.subject.keyword | Metaloproteinase | pt_BR |
| dc.subject.keyword | Exercícios físicos | pt_BR |
| dc.rights.license | © 2021 de Sousa Neto et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/ terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). | pt_BR |
| dc.identifier.doi | https://doi.org/10.2147/CIA.S276518 | pt_BR |
| dc.description.abstract1 | Background: Aging decreases osteogenic ability, inducing harmful effects on the bone extracellular matrix (ECM), while exercise training has been indicated as a tool to counteract bone disorders related to advancing age. The modulation of bone ECM is regulated by several types of matrix metalloproteinase (MMP); however, MMP-2 activity in different trabecular bones in response to resistance training (RT) has been neglected. Remodeling differs in different bones under the application of the same mechanical loading. Thus, we investigated the effects of 12 weeks of RT on MMP-2 activity in the lumbar vertebra (L6), tibia, and femur of young (3 months) and older rats (21 months).
Methods: Twenty Wistar rats were divided into four groups (five animals per group): young sedentary or trained and older sedentary or trained. The 12-week RT consisted of climbing a 1.1-m vertical ladder three times per week with progressive weights secured to the animals’ tails. The animals were killed 48 h after the end of the experimental period. The MMP-2 activity was assessed by the zymography method.
Results: The aging process induced lower MMP-2 activity in the lumbar vertebrae and tibia (p=0.01). RT upregulated pro, intermediate, and active MMP-2 activity in the tibia of young rats (p=0.001). RT also upregulated pro and active MMP-2 activity in the lumbar vertebrae and tibia with advancing age (p=0.01). There was no significant difference (p> 0.05) between groups for MMP-2 of the femur, regardless of age and RT.
Conclusion: The aging process impairs MMP-2 activity, but RT is a potential therapeutic approach to minimize the deleterious effects of ECM degeneration in different aged bones. Distinct MMP-2 responses to exercise training may result in specific remodeling processes. | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-1479-5866 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-2372-7814 | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0001-9126-3882 | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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