Targeted clindamycin delivery to pilosebaceous units by chitosan or hyaluronic acid nanoparticles for improved topical treatment of acne vulgaris

Tolentino, Seila; Pereira, Maira N.; Cunha Filho, Marcílio Sérgio Soares da; Gratieri, Taís; Gelfuso, Guilherme Martins

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Campo DC	Valor	Idioma
dc.contributor.author	Tolentino, Seila	-
dc.contributor.author	Pereira, Maira N.	-
dc.contributor.author	Cunha Filho, Marcílio Sérgio Soares da	-
dc.contributor.author	Gratieri, Taís	-
dc.contributor.author	Gelfuso, Guilherme Martins	-
dc.date.accessioned	2021-03-08T13:34:28Z	-
dc.date.available	2021-03-08T13:34:28Z	-
dc.date.issued	2020-10-22	-
dc.identifier.citation	TOLENTINO, Seila et al. Targeted clindamycin delivery to pilosebaceous units by chitosan or hyaluronic acid nanoparticles for improved topical treatment of acne vulgaris. Carbohydrate Polymers, v. 253, 1 fev. 2021, 117295. DOI: https://doi.org/10.1016/j.carbpol.2020.117295. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0144861720314685.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/40182	-
dc.language.iso	Inglês	pt_BR
dc.publisher	Elsevier Ltd.	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	Targeted clindamycin delivery to pilosebaceous units by chitosan or hyaluronic acid nanoparticles for improved topical treatment of acne vulgaris	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Acne vulgar	pt_BR
dc.subject.keyword	Deposição folicular	pt_BR
dc.subject.keyword	Nanopartículas poliméricas	pt_BR
dc.subject.keyword	Pele	pt_BR
dc.identifier.doi	https://doi.org/10.1016/j.carbpol.2020.117295	pt_BR
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/abs/pii/S0144861720314685	pt_BR
dc.description.abstract1	We developed chitosan or hyaluronic acid nanoparticles to entrap clindamycin and evaluated for the first time the impact of these two polymeric nanosystems on the targeted drug delivery to the pilosebaceous units, considering the sebaceous characteristics of skin affected by acne. Chitosan and hyaluronic acid nanoparticles respectively presented diameters of 362 ± 19 nm and 417 ± 9 nm (PDI < 0.47), entrapped 42 % and 48 % of the clindamycin content (drug loading of 8.8 % and 0.5 %) and had opposite surface charges (+27.7 ± 0.9 mV and -30.2 ± 2.7 mV). Although only the hyaluronic acid nanoparticles showed increased deposition of the drug into the pilosebaceous structures, both nanoparticles revealed enhanced targeted delivery of clindamycin to these structures as compared to commercial formulation (53 ± 20 % and 77 ± 9% of the total drug that penetrated the skin was found on the pilosebaceous units from, respectively, chitosan and hyaluronic acid nanoparticles). Remarkably, the “targeting potential” of the nanoparticles was more pronounced when the skin was pretreated to simulate a sebaceous condition. In conclusion, both polymeric nanocarriers targeted drug delivery to the pilosebaceous structures at different extensions and, in the case of oily skin conditions, such targeting was increased.	pt_BR
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