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dc.contributor.authorMarques, Claudia Diniz Lopes-
dc.contributor.authorKakehasi, Adriana Maria-
dc.contributor.authorPinheiro, Marcelo Medeiros-
dc.contributor.authorMota, Licia Maria Henrique-
dc.contributor.authorAlbuquerque, Cleandro Pires-
dc.contributor.authorSilva, Carolina Rocha-
dc.contributor.authorSantos, Gabriela Porfirio Jardim-
dc.contributor.authorReis Neto, Edgard Torres-
dc.contributor.authorMatos, Pedro-
dc.contributor.authorDevide, Guilherme-
dc.contributor.authorDantas, Andrea-
dc.contributor.authorGiorgi, Rina Dalva-
dc.contributor.authorOmura, Felipe-
dc.contributor.authorMarinho, Adriana de Oliveira-
dc.contributor.authorValadares, Lilian David Azevedo-
dc.contributor.authorMelo, Ana Karla G.-
dc.contributor.authorRibeiro, Francinne Machado-
dc.contributor.authorFerreira, Gilda Aparecida-
dc.contributor.authorSantos, Flavia Patricia de Sena-
dc.contributor.authorRibeiro, Sandra Lucia Euzebio-
dc.contributor.authorAndrade, Nicole Pamplona Bueno-
dc.contributor.authorYazbek, Michel Alexandre-
dc.contributor.authorSouza, Viviane Angelina de-
dc.contributor.authorPaiva, Eduardo S.-
dc.contributor.authorAzevedo, Valderilio Feijo-
dc.contributor.authorFreitas, Ana Beatriz Santos Bacchiega de-
dc.contributor.authorProvenza, José Roberto-
dc.contributor.authorToledo, Ricardo Acayaba de-
dc.contributor.authorFontenelle, Sheilla-
dc.contributor.authorCarneiro, Sueli-
dc.contributor.authorXavier, Ricardo-
dc.contributor.authorPileggi, Gecilmara Cristina Salviato-
dc.contributor.authorReis, Ana Paula Monteiro Gomides-
dc.date.accessioned2021-03-30T17:56:11Z-
dc.date.available2021-03-30T17:56:11Z-
dc.date.issued2021-
dc.identifier.citationMARQUES, Claudia Diniz Lopes et al. High levels of immunosuppression are related to unfavourable outcomes in hospitalised patients with rheumatic diseases and COVID-19: first results of ReumaCoV Brasil registry. RMD Open, v. 7, n. 1, e001461, 2021. DOI: http://dx.doi.org/10.1136/rmdopen-2020-001461. Disponível em: https://rmdopen.bmj.com/content/7/1/e001461. Acesso em: 31 mar. 2021.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/40399-
dc.language.isoInglêspt_BR
dc.publisherBMJ Journalspt_BR
dc.rightsAcesso Abertopt_BR
dc.titleHigh levels of immunosuppression are related to unfavourable outcomes in hospitalised patients with rheumatic diseases and COVID-19 : first results of ReumaCoV Brasil registrypt_BR
dc.typeArtigopt_BR
dc.subject.keywordPacientespt_BR
dc.subject.keywordReumatismopt_BR
dc.subject.keywordCovid-19pt_BR
dc.rights.licenseOpen access - This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work noncommercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/ licenses/by-nc/4.0/. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1136/rmdopen-2020-001461pt_BR
dc.description.abstract1Objectives To evaluate risk factors associated with unfavourable outcomes: emergency care, hospitalisation, admission to intensive care unit (ICU), mechanical ventilation and death in patients with immune-mediated rheumatic disease (IMRD) and COVID-19. Methods Analysis of the first 8 weeks of observational multicentre prospective cohort study (ReumaCoV Brasil register). Patients with IMRD and COVID-19 according to the Ministry of Health criteria were classified as eligible for the study. Results 334 participants were enrolled, a majority of them women, with a median age of 45 years; systemic lupus erythematosus (32.9%) was the most frequent IMRD. Emergency care was required in 160 patients, 33.0% were hospitalised, 15.0% were admitted to the ICU and 10.5% underwent mechanical ventilation; 28 patients (8.4%) died. In the multivariate adjustment model for emergency care, diabetes (prevalence ratio, PR 1.38; 95% CI 1.11 to 1.73; p=0.004), kidney disease (PR 1.36; 95% CI 1.05 to 1.77; p=0.020), oral glucocorticoids (GC) (PR 1.49; 95% CI 1.21 to 1.85; p<0.001) and pulse therapy with methylprednisolone (PR 1.38; 95% CI 1.14 to 1.67; p=0.001) remained significant; for hospitalisation, age >50 years (PR 1.89; 95% CI 1.26 to 2.85; p=0.002), no use of tumour necrosis factor inhibitor (TNFi) (PR 2.51;95% CI 1.16 to 5.45; p=0.004) and methylprednisolone pulse therapy (PR 2.50; 95% CI 1.59 to 3.92; p<0.001); for ICU admission, oral GC (PR 2.24; 95% CI 1.36 to 3.71; p<0.001) and pulse therapy with methylprednisolone (PR 1.65; 95% CI 1.00 to 2.68; p<0.043); the two variables associated with death were pulse therapy with methylprednisolone or cyclophosphamide (PR 2.86; 95% CI 1.59 to 5.14; p<0.018). Conclusions Age >50 years and immunosuppression with GC and cyclophosphamide were associated with unfavourable outcomes of COVID-19. Treatment with TNFi may have been protective, perhaps leading to the COVID-19 inflammatory process.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3333-2621pt_BR
dc.description.unidadeFaculdade de Medicina (FMD)-
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