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dc.contributor.authorKurizky, Patricia Shu-
dc.contributor.authorNóbrega, Otávio de Tolêdo-
dc.contributor.authorSoares, Alexandre Anderson de Sousa Munhoz-
dc.contributor.authorAires, Rodrigo Barbosa-
dc.contributor.authorAlbuquerque, Cleandro Pires de-
dc.contributor.authorNicola, André Moraes-
dc.contributor.authorAndrade, Patrícia Albuquerque de-
dc.contributor.authorCarvalho, Andréa Teixeira-
dc.contributor.authorNaves, Luciana Ansaneli-
dc.contributor.authorFontes, Wagner-
dc.contributor.authorLuz, Isabelle Souza-
dc.contributor.authorFelicori, Liza-
dc.contributor.authorGomides, Ana Paulo Monteiro-
dc.contributor.authorSilva, Dayde Lane Mendonça-
dc.contributor.authorEspindola, Laila Salmen-
dc.contributor.authorMartins Filho, Olindo Assis-
dc.contributor.authorLima, Sheila Maria Barbosa de-
dc.contributor.authorMota, Licia Maria Henrique-
dc.contributor.authorGomes, Ciro Martins-
dc.date.accessioned2021-04-14T17:13:16Z-
dc.date.available2021-04-14T17:13:16Z-
dc.date.issued2021-03-04-
dc.identifier.citationKURIZKY, Patricia et al. Molecular and Cellular Biomarkers of COVID-19 Prognosis: Protocol for the Prospective Cohort TARGET Study. JMIR Research Protocols, v. 10, p. e24211, 2021. DOI: dx.doi.org/10.2196/24211. Disponível em: https://www.researchprotocols.org/2021/3/e24211. Acesso em: 14 abr. 2021.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/40537-
dc.language.isoInglêspt_BR
dc.publisherJMIR Publicationspt_BR
dc.rightsAcesso Abertopt_BR
dc.titleMolecular and cellular biomarkers of COVID-19 prognosis : protocol for the prospective cohort TARGET studypt_BR
dc.typeArtigopt_BR
dc.subject.keywordCovid-19pt_BR
dc.subject.keywordCitocinaspt_BR
dc.subject.keywordTromboelastometriapt_BR
dc.subject.keywordProteômicapt_BR
dc.subject.keywordMetabolômicapt_BR
dc.subject.keywordBiomarcadorespt_BR
dc.subject.keywordImunologiapt_BR
dc.subject.keywordSistema imunológicopt_BR
dc.subject.keywordGenéticapt_BR
dc.rights.license©Patricia Kurizky, Otávio T Nóbrega, Alexandre Anderson De Sousa Munhoz Soares, Rodrigo Barbosa Aires, Cleandro Pires De Albuquerque, André Moraes Nicola, Patrícia Albuquerque, Andréa Teixeira-Carvalho, Luciana Ansaneli Naves, Wagner Fontes, Isabelle Souza Luz, Liza Felicori, Ana Paulo Monteiro Gomides, Dayde Lane Mendonça-Silva, Laila Salmen Espindola, Olindo Assis Martins-Filho, Sheila Maria Barbosa de Lima, Licia Maria Henrique Mota, Ciro Martins Gomes. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 04.03.2021. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on http://www.researchprotocols.org, as well as this copyright and license information must be included.pt_BR
dc.identifier.doidx.doi.org/10.2196/24211pt_BR
dc.description.abstract1Background: Since the beginning of the COVID-19 pandemic, the world’s attention has been focused on better understanding the relation between the human host and the SARS-CoV-2 virus, as its action has led to hundreds of thousands of deaths. Objective: In this context, we decided to study certain consequences of the abundant cytokine release over the innate and adaptive immune systems, inflammation, and hemostasis, comparing mild and severe forms of COVID-19. Methods: To accomplish these aims, we will analyze demographic characteristics, biochemical tests, immune biomarkers, leukocyte phenotyping, immunoglobulin profile, hormonal release (cortisol and prolactin), gene expression, thromboelastometry, neutralizing antibodies, metabolic profile, and neutrophil function (reactive oxygen species production, neutrophil extracellular trap production, phagocytosis, migration, gene expression, and proteomics). A total of 200 reverse transcription polymerase chain reaction–confirmed patients will be enrolled and divided into two groups: mild/moderate or severe/critical forms of COVID-19. Blood samples will be collected at different times: at inclusion and after 9 and 18 days, with an additional 3-day sample for severe patients. We believe that this information will provide more knowledge for future studies that will provide more robust and useful clinical information that may allow for better decisions at the front lines of health care. Results: The recruitment began in June 2020 and is still in progress. It is expected to continue until February 2021. Data analysis is scheduled to start after all data have been collected. The coagulation study branch is complete and is already in the analysis phase.pt_BR
dc.description.unidadeFaculdade de Medicina (FMD)-
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UnB - Covid-19

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