Título:	Biomarkers in colorectal cancer : the role of translational proteomics research
Autor(es):	Martins, Bruno Augusto Alves Bulhões, Gabriel Fonseca de Cavalcanti, Igor Norat Martins, Mickaella Michelson Oliveira, Paulo Gonçalves de Martins, Aline Maria Araújo
Assunto:	Cólon (Anatomia) - câncer Biomarcadores Proteômica Espectrometria de massa
Data de publicação:	2019
Editora:	Frontiers
Referência:	MARTINS, Bruno Augusto Alves et al. Biomarkers in colorectal cancer: the role of translational proteomics research. Frontiers in Oncology, v. 9, 1284, 2019. DOI: 10.3389/fonc.2019.01284. Disponível em: https://www.frontiersin.org/articles/10.3389/fonc.2019.01284/full. Acesso em: 14 maio 2021.
Abstract:	Colorectal cancer is one of the most common cancers in the world, and it is one of the leading causes of cancer-related death. Despite recent progress in the development of screening programs and in the management of patients with colorectal cancer, there are still many gaps to fill, ranging from the prevention and early diagnosis to the determination of prognosis factors and treatment of metastatic disease, to establish a personalized approach. The genetic profile approach has been increasingly used in the decision-making process, especially in the choice of targeted therapies and in the prediction of drug response, but there are still few validated biomarkers of colorectal cancer for clinical practice. The discovery of non-invasive, sensitive, and specific biomarkers is an urgent need, and translational proteomics play a key role in this process, as they enable better comprehension of colorectal carcinogenesis, identification of potential markers, and subsequent validation. This review provides an overview of recent advances in the search for colorectal cancer biomarkers through proteomics studies according to biomarker function and clinical application.
Unidade Acadêmica:	Faculdade de Medicina (FMD)
Licença:	(CC BY) - Copyright © 2019 Alves Martins, de Bulhões, Cavalcanti, Martins, de Oliveira and Martins. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
DOI:	https://doi.org/10.3389/fonc.2019.01284
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