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Universidade de Brasília
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dc.contributor.authorGasca, Cristian A.-
dc.contributor.authorMoreira, Natalia C. S.-
dc.contributor.authorAlmeida, Fernanda C. de-
dc.contributor.authorGomes, João Victor Dutra-
dc.contributor.authorCastillo, Willian O.-
dc.contributor.authorFagg, Christopher William-
dc.contributor.authorBatista, Pérola de Oliveira Magalhães Dias-
dc.contributor.authorFonseca-Bazzo, Yris Maria-
dc.contributor.authorSakamoto-Hojo, Elza-
dc.contributor.authorMedeiros, Yanna K. de-
dc.contributor.authorBorges, Warley de Souza-
dc.contributor.authorSilveira, Dâmaris-
dc.date.accessioned2021-05-26T14:43:06Z-
dc.date.available2021-05-26T14:43:06Z-
dc.date.issued2020-
dc.identifier.citationGASCA, Cristian A. et al. Acetylcholinesterase inhibitory activity, anti-inflammatory, and neuroprotective potential of Hippeastrum psittacinum (Ker Gawl.) herb (Amaryllidaceae). Food and Chemical Toxicology, v. 145, 111703, 2020. DOI: https://doi.org/10.1016/j.fct.2020.111703.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/41037-
dc.language.isoInglêspt_BR
dc.publisherElsevier Ltd.pt_BR
dc.rightsAcesso Restritopt_BR
dc.titleAcetylcholinesterase inhibitory activity, anti-inflammatory, and neuroprotective potential of Hippeastrum psittacinum (Ker Gawl.) herb (Amaryllidaceae)pt_BR
dc.typeArtigopt_BR
dc.subject.keywordAmaryllidaceaept_BR
dc.subject.keywordAlcalóidespt_BR
dc.subject.keywordAcetilcolinesterasept_BR
dc.subject.keywordAgentes antiinflamatóriospt_BR
dc.subject.keywordAlzheimer, Doença dept_BR
dc.identifier.doihttps://doi.org/10.1016/j.fct.2020.111703pt_BR
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0278691520305937pt_BR
dc.description.abstract1Hippeastrum psittacinum, Amaryllidaceae, is used in traditional medicine as a purgative, aphrodisiac, and anticough remedy. The ethanol extract (EE) and alkaloid-rich fractions (ARF) from H. psittacinum bulbs were evaluated for their acetylcholinesterase (AChE) inhibition. The EE cytotoxic and anti-inflammatory effects in RAW 264.7 cells, and the neuroprotective and genotoxic activities in SH-SY5Y cells, were also estimated. Fifteen alkaloids were identified in the EE by gas chromatography–mass spectrometry. ARFs were less active for AChE inhibition than EE. The viability of both cell lines was higher than 70% with EE concentrations below 25 μg/mL. The EE decreased nitrite release in RAW cells stimulated with lipopolysaccharide, showing values of 83, 67, and 53% at 6.25, 12.5, and 25 μg/mL, respectively. Furthermore, the EE partially protected SH-SY5Y cells from hydrogen peroxide-mediated deleterious effects by approximately 50% at the same concentrations. The micronucleus assays showed that the extract caused chromosomal missegregation at concentrations above 12.5 μg/mL. The in silico analyses showed that some alkaloids presented properties of permeation of the blood-brain barrier and the intestine. Our findings present new evidence of the potential of H. psittacinum potential as an AChE inhibitor, as well as an anti-inflammatory and neuroprotective agent.pt_BR
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