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dc.contributor.authorCerqueira, Adara Rodrigues Damasceno-
dc.contributor.authorFratelli, Caroline Ferreira-
dc.contributor.authorDuarte, Ligia Canongia de Abreu Cardoso-
dc.contributor.authorPereira, Alexandre Sampaio Rodrigues-
dc.contributor.authorMorais, Rafael Martins de-
dc.contributor.authorBarra Sobrinho, Alaor-
dc.contributor.authorSilva, Calliandra Maria de Souza-
dc.contributor.authorSilva, Izabel Cristina Rodrigues da-
dc.contributor.authorOliveira, Jamila Reis de-
dc.date.accessioned2021-07-28T02:04:44Z-
dc.date.available2021-07-28T02:04:44Z-
dc.date.issued2020-
dc.identifier.citationCERQUEIRA, Adara Rodrigues Damasceno. The impact of NOS3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapy. The International Journal of Biological Markers, v. 35, n. 4, p. 87-91, 2020. DOI: https://doi.org/10.1177/1724600820961787. Disponível em: https://journals.sagepub.com/doi/full/10.1177/1724600820961787. Acesso em: 26 jul. 2021.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/41510-
dc.language.isoInglêspt_BR
dc.publisherSagept_BR
dc.rightsAcesso Abertopt_BR
dc.titleThe impact of NOS3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapypt_BR
dc.typeArtigopt_BR
dc.subject.keywordPolimorfismo (Genética)pt_BR
dc.subject.keywordTireóide - câncerpt_BR
dc.subject.keywordTireoidectomiapt_BR
dc.subject.keywordÓxido nítricopt_BR
dc.rights.licenseCreative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).pt_BR
dc.identifier.doihttps://doi.org/10.1177/1724600820961787pt_BR
dc.description.abstract1Thyroid cancer is the most common endocrine cancer in the world. Noting that the NOS3 gene polymorphism interferes with nitric oxide production, this study aims to identify and analyze the NOS3 gene polymorphism in the intron 4 region in patients with papillary thyroid cancer. A case-control study was conducted with 31 papillary thyroid cancer patients of both genders who underwent thyroidectomy and treatment with sodium iodide radiopharmaceutical (131I) compared with 81 control patients. Through papillary thyroid cancer, the results were observed, compiled, and analyzed using SPSS version 25.0. The significance level of 5% was adopted. Genotypic frequencies of healthy subjects were in the Hardy-Weinberg equilibrium (P = 0.503). There was a significant genotypic difference between papillary thyroid cancer and healthy individuals (P <0.001). The BB genotype conferred a protective factor for papillary thyroid cancer (P <0.001, odds ratio (OR) 0.16; 95% confidence interval (CI) 0.06, 0.42), while the presence of the A allele appears to be a risk factor for papillary thyroid cancer (P <0.001, OR 3.54; 95% CI 1.86, 6.73). The intron 4 polymorphism of the NOS3 gene was associated with susceptibility to papillary thyroid cancer. Thus, future research into the effects of this polymorphism is essential.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-0511-9452pt_BR
dc.description.unidadeFaculdade UnB Ceilândia (FCE)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências e Tecnologias em Saúdept_BR
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