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dc.contributor.authorSchweitzer, Guilherme R. B.-
dc.contributor.authorRios, Isabela N. M. S.-
dc.contributor.authorGonçalves, Vivian Siqueira Santos-
dc.contributor.authorMagalhães, Kelly Grace-
dc.contributor.authorPizato, Nathalia Marcolini Pelucio-
dc.date.accessioned2021-08-23T18:50:34Z-
dc.date.available2021-08-23T18:50:34Z-
dc.date.issued2021-07-21-
dc.identifier.citationSCHWEITZER, Guilherme R. B. et al. Effect of n-3 long-chain polyunsaturated fatty acid intake on the eicosanoid profile in individuals with obesity and overweight: a systematic review and meta-analysis of clinical trials. Journal of Nutritional Science, v. 10, e53, 2021. DOI: https://doi.org/10.1017/jns.2021.46. Disponível em: https://www.cambridge.org/core/journals/journal-of-nutritional-science/article/effect-of-n3-longchain-polyunsaturated-fatty-acid-intake-on-the-eicosanoid-profile-in-individuals-with-obesity-and-overweight-a-systematic-review-and-metaanalysis-of-clinical-trials/20E7644BFC5F5ED2237A40815FE6A998. Acesso em: 23 ago. 2021.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/41869-
dc.language.isoInglêspt_BR
dc.publisherCambridge University Press on behalf of The Nutrition Societypt_BR
dc.rightsAcesso Abertopt_BR
dc.titleEffect of n-3 long-chain polyunsaturated fatty acid intake on the eicosanoid profile in individuals with obesity and overweight : a systematic review and meta-analysis of clinical trialspt_BR
dc.typeArtigopt_BR
dc.subject.keywordEucosanóidespt_BR
dc.subject.keywordInflamaçãopt_BR
dc.subject.keywordn- 3 PUFApt_BR
dc.subject.keywordObesidadept_BR
dc.subject.keywordRevisão sistemáticapt_BR
dc.rights.license© The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Society. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.pt_BR
dc.identifier.doihttps://doi.org/10.1017/jns.2021.46pt_BR
dc.description.abstract1Dietary n-3 polyunsaturated fatty acids (PUFAs) present beneficial effects on counteracting inflammation status, displaying a critical anti-inflammatory role and maintaining physiological homeostasis in obesity. The primary objective of this systematic review was to evaluate the effect of n-3 PUFAs intake on the eicosanoid profile of people with obesity and overweight. The search strategy on Embase, Scopus, PubMed, Web of Science, Cochrane Library, Google Scholar and ProQuest was undertaken until November 2019 and updated January 2021. The effect size of n-3 PUFAs on prostaglandins was estimated by Glass's, type 1 in a random-effect model for the meta-analysis. Seven clinical trials met the eligible criteria and a total of 610 subjects were included in this systematic review, and four of seven studies were included in meta-analysis. The intake of n-3 PUFAs promoted an overall reduction in serum pro-inflammatory eicosanoids. Additionally, n-3 PUFAs intake significantly decreased the arachidonic acid COX-derived PG eicosanoid group levels (Glass's Δ −0⋅35; CI −0⋅62, −0⋅07, I2 31⋅48). Subgroup analyses showed a higher effect on periods up to 8 weeks (Glass's Δ −0⋅51; CI −0⋅76, −0⋅27) and doses higher than 0⋅5 g of n-3 PUFAs (Glass's Δ −0⋅46; CI −0⋅72, −0⋅27). Dietary n-3 PUFAs intake contributes to reduce pro-inflammatory eicosanoids of people with obesity and overweight. Subgroup's analysis showed that n-3 PUFAs can reduce the overall arachidonic acid COX-derived PG when adequate dose and period are matched.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7435-5272pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5858-7076pt_BR
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