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dc.contributor.authorNunes, Ricardo Ferreira-
dc.contributor.authorCunha Filho, Marcílio Sérgio Soares da-
dc.contributor.authorGratieri, Taís-
dc.contributor.authorGelfuso, Guilherme Martins-
dc.date.accessioned2021-11-10T15:21:38Z-
dc.date.available2021-11-10T15:21:38Z-
dc.date.issued2021-
dc.identifier.citationNUNES, Ricardo Ferreira et al. Follicular-targeted delivery of spironolactone provided by polymeric nanoparticles. Colloids and Surfaces B: Biointerfaces, v. 208, 112101, 2021. DOI: https://doi.org/10.1016/j.colsurfb.2021.112101.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/42350-
dc.language.isoInglêspt_BR
dc.publisherElsevier B.V.pt_BR
dc.rightsAcesso Restritopt_BR
dc.titleFollicular-targeted delivery of spironolactone provided by polymeric nanoparticlespt_BR
dc.typeArtigopt_BR
dc.subject.keywordAcnept_BR
dc.subject.keywordAlopeciapt_BR
dc.subject.keywordFolículo capilarpt_BR
dc.subject.keywordCopolímero de ácido metacrílico / metacrilato de metilapt_BR
dc.subject.keywordPoli-ε-caprolactonapt_BR
dc.identifier.doihttps://doi.org/10.1016/j.colsurfb.2021.112101pt_BR
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0927776521005452?via%3Dihubpt_BR
dc.description.abstract1This study proposes developing a topical formulation based on poly-ε-caprolactone (PCL) or methacrylic acid/methyl methacrylate copolymer (EL100) nanoparticles to enable a safer and more effective therapy of alopecia and acne with spironolactone. The effect of the size of the nanoparticle on follicular-targeted drug delivery is also verified. Compatibility studies based on thermal analyses and complementary techniques showed a small interaction of the drug with excipients, which may not compromise the drug stability. PCL nanoparticles of 180.0 ± 1.6 and 126.8 ± 1.0 nm, and EL100 nanoparticles of 102.7 ± 7.1 nm were then prepared. All nanoparticles entrapped more than 75 % of spironolactone, were physically stable, and stabilized the drug for at least 90 days. They were also non-irritant according to HET-CAM tests. Drug release from the nanoparticles was reduced in aqueous buffer media but fast when in contact with oil. Finally, in vitro skin penetration experiments revealed the largest nanoparticles (of 180 nm) targeted drug delivery to the hair follicles 5-fold (p < 0.05) more than the control solution, 2.1-fold (p < 0.05) more than nanoparticles produced with the same polymer (PCL) but with smaller size (123 nm), and 4.9-fold (p < 0.05) more than the 102-nm E100 nanoparticles. In conclusion, follicular targeting can be adjusted according to nanoparticle size, and this work succeeded in obtaining polymeric nanoparticles adequate to enable topical treatment of acne and alopecia with spironolactone.pt_BR
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