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dc.contributor.authorBarbalho, Geisa Nascimento-
dc.contributor.authorMatos, Breno Noronha-
dc.contributor.authorBrito, Gabriel Ferreira da Silva-
dc.contributor.authorMiranda, Thamires da Cunha-
dc.contributor.authorAlencar-Silva, Thuany-
dc.contributor.authorFabriz Sodré, Fernando-
dc.contributor.authorGelfuso, Guilherme Martins-
dc.contributor.authorCunha Filho, Marcílio Sérgio Soares da-
dc.contributor.authorCarvalho, Juliana Lott de-
dc.contributor.authorSilva, Joyce Kelly do Rosário da-
dc.contributor.authorGratieri, Taís-
dc.date.accessioned2022-04-26T15:51:22Z-
dc.date.available2022-04-26T15:51:22Z-
dc.date.issued2022-01-16-
dc.identifier.citationBARBALHO, Geisa Nascimento et al. Skin regenerative potential of Cupuaçu seed extract (Theobroma grandiflorum), a native fruit from the Amazon: development of a topical formulation based on chitosan-coated nanocapsules. Pharmaceutics, v. 14, 207, 2022. DOI: https://doi.org/10.3390/pharmaceutics14010207. Disponível em: https://www.mdpi.com/1999-4923/14/1/207. Acesso em: 26 abr. 2022.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/43541-
dc.language.isoInglêspt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleSkin regenerative potential of Cupuaçu seed extract (Theobroma grandiflorum), a native fruit from the Amazon : development of a topical formulation based on chitosan-coated nanocapsulespt_BR
dc.typeArtigopt_BR
dc.subject.keywordNanocápsulaspt_BR
dc.subject.keywordExtrato de semente de cupuaçupt_BR
dc.subject.keywordPele - queimaduraspt_BR
dc.subject.keywordPele - regeneraçãopt_BR
dc.subject.keywordÁcido oleicopt_BR
dc.rights.licenseCopyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/pharmaceutics14010207pt_BR
dc.description.abstract1Scarless skin regeneration is a challenge in regenerative medicine. Herein, we explore the regenerative potential of a Cupuaçu seed extract (Theobroma grandiflorum) to develop an innovative skin regeneration formulation based on chitosan-coated nanocapsules. Cupuaçu seed extract significantly stimulated cell proliferation and migration. A reparative gene expression profile could be verified following extract treatment, which included high levels of MKI67, a cellular proliferation marker, and extracellular matrix genes, such as ELN and HAS2, which code for elastin and hyaluronic acid synthase 2. Formulations with Cupuaçu seed extract successfully entrapped into nanocapsules (EE% > 94%) were developed. Uncoated or coated nanocapsules with low-molecular-weight chitosan presented unimodal size distribution with hydrodynamic diameters of 278.3 ± 5.0 nm (PDI = 0.18 ± 0.02) and 337.2 ± 2.1 nm (PDI = 0.27 ± 0.01), respectively. Both nanosystems were physically stable for at least 120 days and showed to be non-irritating to reconstructed human epidermis. Chitosan coating promoted active penetration into undamaged skin areas, which were still covered by the stratum corneum. In conclusion, the present study demonstrated for the first time the biotechnological potential of the frequently discarded Cupuaçu seed as a valuable pharmaceutical ingredient to be used in regenerative skin products.pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-9605-4171pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-1924-7885pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0002-9167-6852pt_BR
dc.identifier.orcidhttps://orcid.org/ 0000-0001-6481-2364pt_BR
dc.description.unidadeFaculdade de Medicina (FMD)pt_BR
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