A mathematical model for treatment of papillary thyroid cancer using the allee effect

Silva, Jairo Gomes da; Morais, Rafael Martins de; Silva, Izabel Cristina Rodrigues da; Adimy, Mostafa; Mancera, Paulo Fernando de Arruda

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Campo DC	Valor	Idioma
dc.contributor.author	Silva, Jairo Gomes da	-
dc.contributor.author	Morais, Rafael Martins de	-
dc.contributor.author	Silva, Izabel Cristina Rodrigues da	-
dc.contributor.author	Adimy, Mostafa	-
dc.contributor.author	Mancera, Paulo Fernando de Arruda	-
dc.date.accessioned	2022-07-06T11:06:01Z	-
dc.date.available	2022-07-06T11:06:01Z	-
dc.date.issued	2020	-
dc.identifier.citation	SILVA, Jairo Gomes da et al. A mathematical model for treatment of papillary thyroid cancer using the allee effect. Journal of Biological Systems, v. 28, n. 3, p. 701-718, 2020. DOI: https://doi.org/10.1142/S0218339020500138.	pt_BR
dc.identifier.uri	https://repositorio.unb.br/handle/10482/44113	-
dc.language.iso	Alemão	pt_BR
dc.publisher	World Scientific	pt_BR
dc.rights	Acesso Restrito	pt_BR
dc.title	A mathematical model for treatment of papillary thyroid cancer using the allee effect	pt_BR
dc.type	Artigo	pt_BR
dc.subject.keyword	Tireoide - tumores	pt_BR
dc.subject.keyword	Interleucina 6	pt_BR
dc.subject.keyword	Radioiodina	pt_BR
dc.subject.keyword	Equações diferenciais ordinárias	pt_BR
dc.identifier.doi	https://doi.org/10.1142/S0218339020500138	pt_BR
dc.description.abstract1	The incidence of thyroid cancer is rising all over the world, and the papillary subtype (PTC) is the primary factor for this increase. The presence of thyroid tumors is commonly associated with increased levels of cytokines, such as interleukin 6 (IL-6). Considering PTC patients treated with thyroidectomy and radioactive iodine 131I (RAI), we propose an ordinary differential system using four variables: the RAI activity, the number of cancer cells and the serum concentrations of IL-6 and thyroglobulin (Tg). Our objective is to study the efficacy of different therapeutic doses of RAI in the treatment of thyroid cancer. The Allee effect is taken into account when modeling cancer cells growth under the influence of IL-6. From the results obtained, the main factors and conditions correlated with successful treatment, such as the RAI activity used and the tumor response are addressed. The detection of minimal doses of RAI that can cause tumor extinction is performed, though this has also meant longer periods for tumor cell elimination. The critical number of tumor cells due to the Allee effect is analyzed and linked to the immune system or biological factors that can slow the progression of the tumor but are insufficient after thyroid resection surgery.	pt_BR
dc.description.unidade	Faculdade UnB Ceilândia (FCE)	-
dc.description.unidade	Curso de Saúde Coletiva (FCE-SC)	-
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