| Élément Dublin Core | Valeur | Langue |
|---|
| dc.contributor.author | Mota, Tales Henrique Andrade da | - |
| dc.contributor.author | Guimarães, Ana Flavia Reis | - |
| dc.contributor.author | Carvalho, Amandda Évelin Silva de | - |
| dc.contributor.author | Araújo, Felipe Saldanha de | - |
| dc.contributor.author | Lopes, Giselle Pinto de Faria | - |
| dc.contributor.author | Pittella-Silva, Fabio | - |
| dc.contributor.author | Rabello, Doralina do Amaral | - |
| dc.contributor.author | Oliveira, Diego Madureira de | - |
| dc.date.accessioned | 2022-09-05T13:07:20Z | - |
| dc.date.available | 2022-09-05T13:07:20Z | - |
| dc.date.issued | 2021 | - |
| dc.identifier.citation | MOTA, Tales Henrique Andrade da et al. Effects of in vitro short- and long-term treatment with telomerase inhibitor in U-251 glioma cells. Tumor Biology, v. 43, p. 327-340, 2021. DOI: 10.3233/TUB-211515. Disponível em: https://content.iospress.com/articles/tumor-biology/tub211515. Acesso em:05 set. 2022. | pt_BR |
| dc.identifier.uri | https://repositorio.unb.br/handle/10482/44690 | - |
| dc.language.iso | Inglês | pt_BR |
| dc.publisher | IOS Press | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Effects of in vitro short- and long-term treatment with telomerase inhibitor in U-251 glioma cells | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Glioma | pt_BR |
| dc.subject.keyword | Telomerase | pt_BR |
| dc.subject.keyword | Câncer - tratamento | pt_BR |
| dc.rights.license | © 2021 – The authors. Published by IOS Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC 4.0) | pt_BR |
| dc.identifier.doi | 10.3233/TUB-211515 | pt_BR |
| dc.description.abstract1 | BACKGROUND: The inhibition of the enzyme telomerase (TERT) has been widely investigated as a new pharmacological
approach for cancer treatment, but its real potential and the biochemical consequences are not totally understood.
OBJECTIVE: Here, we investigated the effects of the telomerase inhibitor MST-312 on a human glioma cell line after both
short- and long-term (290 days) treatments.
METHODS: Effects on cell growth, viability, cell cycle, morphology, cell death and genes expression were assessed.
RESULTS: We found that short-term treatment promoted cell cycle arrest followed by apoptosis. Importantly, cells with
telomerase knock-down revealed that the toxic effects of MST-312 are partially TERT dependent. In contrast, although the
long-term treatment decreased cell proliferation at first, it also caused adaptations potentially related to treatment resistance
and tumor aggressiveness after long time of exposition.
CONCLUSIONS: Despite the short-term effects of telomerase inhibition not being due to telomere erosion, they are at
least partially related to the enzyme inhibition, which may represent an important strategy to pave the way for tumor growth
control, especially through modulation of the non-canonical functions of telomerase. On the other hand, long-term exposure
to the inhibitor had the potential to induce cell adaptations with possible negative clinical implications. | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0002-6272-6558 | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Faculdade UnB Ceilândia | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Faculdade de Ciências da Saúde, Departamento de Farmácia | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Faculdade de Ciências da Saúde, Departamento de Farmácia | pt_BR |
| dc.contributor.affiliation | Universidade de Brasília, Faculdade de Ciências da Saúde, Departamento de Farmácia | pt_BR |
| dc.contributor.affiliation | Laboratório de Hemato-oncologia Celular e Molecular, Instituto Nacional do Câncer (INCA) | pt_BR |
| dc.contributor.affiliation | Departamento de Biotecnologia Marinha, Instituto de Estudos do Mar do Almirante Paulo Moreira, IEAPM | pt_BR |
| Collection(s) : | Artigos publicados em periódicos e afins
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