Skip navigation
Use este identificador para citar ou linkar para este item: http://repositorio.unb.br/handle/10482/45099
Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
ARTIGO_PouteriaMacrophyllaFruit.pdf3,08 MBAdobe PDFVisualizar/Abrir
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorBrathwaite, Ana Clara Nogueira-
dc.contributor.authorSilva, Thuany Alencar-
dc.contributor.authorCarvalho, Larissa A. C.-
dc.contributor.authorBranquinho, Maryana Stephany Ferreira-
dc.contributor.authorNunes, Ricardo Ferreira-
dc.contributor.authorCunha Filho, Marcílio Sérgio Soares da-
dc.contributor.authorGelfuso, Guilherme Martins-
dc.contributor.authorMaria-Engler, Silvya Stuchi-
dc.contributor.authorCarvalho, Juliana Lott de-
dc.contributor.authorSilva, Joyce Kelly do Rosário da-
dc.contributor.authorGratieri, Taís-
dc.date.accessioned2022-11-03T22:03:10Z-
dc.date.available2022-11-03T22:03:10Z-
dc.date.issued2022-09-14-
dc.identifier.citationBRATHWAITE, Ana Clara N. et al. Pouteria macrophylla fruit extract microemulsion for cutaneous depigmentation: evaluation using a 3D pigmented skin model. Molecules, Basel, v. 27, n. 18, art. 5982, 2022. DOI 10.3390/molecules27185982. Disponível em: https://www.mdpi.com/1420-3049/27/18/5982. Acesso em: 03 nov. 2022.pt_BR
dc.identifier.urihttps://repositorio.unb.br/handle/10482/45099-
dc.language.isoInglêspt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titlePouteria macrophylla fruit extract microemulsion for cutaneous depigmentation : evaluation using a 3D pigmented skin modelpt_BR
dc.typeArtigopt_BR
dc.subject.keywordExtrato de cutitapt_BR
dc.subject.keywordÁcido gálicopt_BR
dc.subject.keywordHiperpigmentaçãopt_BR
dc.rights.licenseMolecules - No special permission is required to reuse all or part of article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. Reuse of an article does not imply endorsement by the authors or MDPI. Fonte: https://www.mdpi.com/openaccess. Acesso em: 03 nov. 2022.pt_BR
dc.identifier.doihttps://doi.org/10.3390/molecules27185982pt_BR
dc.description.abstract1Here, we verify the depigmenting action of Pouteria macrophylla fruit extract (EXT), incorporate it into a safe topical microemulsion and assess its effectiveness in a 3D pigmented skin model. Melanocytes-B16F10- were used to assess the EXT effects on cell viability, melanin synthesis, and melanin synthesis-related gene transcription factor expression, which demonstrated a 32% and 50% reduction of intra and extracellular melanin content, respectively. The developed microemulsion was composed of Cremophor EL®/Span 80 4:1 (w/w), ethyl oleate, and pH 4.5 HEPES buffer and had an average droplet size of 40 nm (PdI 0.40 ± 0.07). Skin irritation test with reconstituted epidermis (Skin Ethic RHETM) showed that the formulation is non-irritating. Tyrosinase inhibition was maintained after skin permeation in vitro, in which microemulsion showed twice the inhibition of the conventional emulsion (20.7 ± 2.2% and 10.7 ± 2.4%, respectively). The depigmenting effect of the microemulsion was finally confirmed in a 3D culture model of pigmented skin, in which histological analysis showed a more pronounced effect than a commercial depigmenting formulation. In conclusion, the developed microemulsion is a promising safe formulation for the administration of cutite fruit extract, which showed remarkable depigmenting potential compared to a commercial formulation.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-2637-9269pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9167-6852pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1924-7885pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0003-4771-6041pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1423-0523pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9351-876Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-6481-2364pt_BR
dc.contributor.emailmailto:tgratieri@gmail.compt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
Aparece nas coleções:Artigos publicados em periódicos e afins

Mostrar registro simples do item Visualizar estatísticas



Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.