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Title: Coronavirus 2019 disease : are corticosteroids the key treatment? : a retrospective case-control study in Brazil
Authors: Rios, Salete da Silva
Chen, Ana Carolina Rios
Chen, Juliana Rios
Resende, Ceres Nunes de
Araujo Júnior, Edward
metadata.dc.identifier.orcid: https://orcid.org/0000-0003-2798-3564
metadata.dc.contributor.affiliation: University of Brasília, School of Medicine
University of Brasília, School of Medicine
University of Brasília, School of Medicine
University of Brasília, School of Medicine
Federal University of São Paulo, Department of Obstetrics Paulista School of Medicine
Municipal Universidade of São Caetano Do Sul, Medical Course, Bela Vista Campus
Assunto:: Covid-19
Corticóide
Issue Date: 2022
Publisher: Elsevier Ltd on behalf of IJS Publishing Group Ltd.
Citation: RIOS,Salete S. et al. Coronavirus 2019 disease: are corticosteroids the key treatment?: a retrospective case-control study in Brazil. Annals of Medicine and Surgery, [S.l.], v. 82, 104746, 2022. DOI: https://doi.org/10.1016/j.amsu.2022.104746. Disponível em: https://www.sciencedirect.com/science/article/pii/S2049080122015060. Acesso em 08 jul. 2023.
Abstract: Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the putative cause of coronavirus disease 2019 (COVID-19), a serious disease that has severely impacted the world. Although vaccines have been developed, it will take time to inoculate the global population. Current guidelines have focused on the treatment of severe cases in hospital settings; however, a void has been created regarding appropriate measures for those in the initial stage of COVID-19 and those experiencing moderate disease severity progressing to desaturation. We assessed clinical outcomes in patients with COVID-19 with pneumonia at initial presentation treated with corticosteroids. Methods: Data of 177 consecutive high-risk patients with COVID-19, monitored by telemedicine, were collected and analyzed. Of those, 68 patients were in the initial inflammatory phase of the disease without desaturation and received corticosteroids. The outcomes were evaluated after a follow up of 14 days. Four patients were immediately referred to the hospital because they had explicit desaturation at presentation. Results: After 14 days, all patients in the inflammatory phase at presentation who were treated with corticosteroids before desaturation were alive and without complications. However, of the four patients with desaturation, one died at the hospital. Conclusion: In this study, the use of corticosteroids during the initial pulmonary phase of COVID-19 before desaturation, in addition to daily monitoring of patients, prevented disease progression, decreased the risk of complications and incidence of hospitalization and death. However, additional studies with larger number of patients are needed to confirm these findings.
metadata.dc.description.unidade: Faculdade de Medicina (FMD)
Licença:: © 2022 The Authors. Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
DOI: https://doi.org/10.1016/j.amsu.2022.104746
Appears in Collections:Artigos publicados em periódicos e afins
UnB - Covid-19

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