| Campo DC | Valor | Idioma |
|---|
| dc.contributor.author | Araújo, Maísa Miranda | - |
| dc.contributor.author | Botelho, Patrícia Borges | - |
| dc.date.accessioned | 2023-10-02T20:45:00Z | - |
| dc.date.available | 2023-10-02T20:45:00Z | - |
| dc.date.issued | 2022-12-08 | - |
| dc.identifier.citation | ARAÚJO, Maísa Miranda; BOTELHO, Patrícia Borges. Probiotics, prebiotics, and synbiotics in chronic constipation: outstanding aspects to be considered for the current evidence. Frontiers in Nutrition, [s. l.], v. 9, 935830, 2022. DOI: https://doi.org/10.3389/fnut.2022.935830. Disponível em: https://www.frontiersin.org/articles/10.3389/fnut.2022.935830/full. Acesso em: 02 out. 2023. | pt_BR |
| dc.identifier.uri | http://repositorio2.unb.br/jspui/handle/10482/46595 | - |
| dc.language.iso | eng | pt_BR |
| dc.publisher | Frontiers Media | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Probiotics, prebiotics, and synbiotics in chronic constipation : outstanding aspects to be considered for the current evidence | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Sistema gastrointestinal | pt_BR |
| dc.subject.keyword | Probióticos | pt_BR |
| dc.subject.keyword | Constipação intestinal | pt_BR |
| dc.subject.keyword | Prebióticos | pt_BR |
| dc.rights.license | (CC-BY) © 2022 Araújo and Botelho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | pt_BR |
| dc.identifier.doi | https://doi.org/10.3389/fnut.2022 | pt_BR |
| dc.description.abstract1 | This integrative aimed to evaluate the effects and the potential mechanism
of action of prebiotics, probiotics, and synbiotics on constipation-associated
gastrointestinal symptoms and to identify issues that still need to be answered.
A literature search was performed in the PubMed database. Animal models
(n = 23) and clinical trials (n = 39) were included. In animal studies,
prebiotic, probiotic, and synbiotic supplementation showed a decreased
colonic transit time (CTT) and an increase in the number and water content
of feces. In humans, inulin is shown to be the most promising prebiotic,
while B. lactis and L. casei Shirota probiotics were shown to increase
defecation frequency, the latter strain being more effective in improving
stool consistency and constipation symptoms. Overall, synbiotics seem to
reduce CTT, increase defecation frequency, and improve stool consistency
with a controversial effect on the improvement of constipation symptoms.
Moreover, some aspects of probiotic use in constipation-related outcomes
remain unanswered, such as the best dose, duration, time of consumption
(before, during, or after meals), and matrices, as well as their effect and
mechanisms on the regulation of inflammation in patients with constipation,
on polymorphisms associated with constipation, and on the management
of constipation via 5-HT. Thus, more high-quality randomized control
trials (RCTs) evaluating these lacking aspects are necessary to provide safe
conclusions about their effectiveness in managing intestinal constipation. | pt_BR |
| dc.contributor.affiliation | University of Brasília, Faculty of Health Science, Department of Nutrition | pt_BR |
| dc.contributor.affiliation | University of Brasília, Faculty of Health Science, Department of Nutrition | pt_BR |
| dc.description.unidade | Faculdade de Ciências da Saúde (FS) | pt_BR |
| dc.description.unidade | Departamento de Nutrição (FS NUT) | pt_BR |
| Aparece nas coleções: | Artigos publicados em periódicos e afins
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