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dc.contributor.authorFernandes, Geraldo Magela-
dc.contributor.authorMotta, Felipe-
dc.contributor.authorSasaki, Lizandra Moura Paravidine-
dc.contributor.authorSilva, Ângelo Pereira da-
dc.contributor.authorMiranda, Andreza Monforte-
dc.contributor.authorCarvalho, Aleida Oliveira de-
dc.contributor.authorGomides, Ana Paulo Monteiro-
dc.contributor.authorSoares, Alexandre Anderson de Sousa Munhoz-
dc.contributor.authorSantos Junior, Agenor de Castro Moreira dos-
dc.contributor.authorAlves, Caroline de Oliveira-
dc.contributor.authorGomes, Ciro Martins-
dc.contributor.authorSiracusa, Clara Correia de-
dc.contributor.authorAraújo Júnior, David Alves de-
dc.contributor.authorSilva, Dayde Lane Mendonça da-
dc.contributor.authorJesus, José Alfredo Lacerda de-
dc.contributor.authorCosta, Karina Nascimento-
dc.contributor.authorCastro, Maria Eduarda Canellas de-
dc.contributor.authorKurizky, Patricia Shu-
dc.contributor.authorFrança, Paulo Sérgio-
dc.contributor.authorTristão, Rosana Maria-
dc.contributor.authorPereira, Yacara Ribeiro-
dc.contributor.authorCastro, Luiz Claudio Gonçalves de-
dc.contributor.authorZaconeta, Alberto Carlos Moreno-
dc.contributor.authorAlbuquerque, Cleandro Pires de-
dc.contributor.authorMota, Licia Maria Henrique da-
dc.date.accessioned2023-10-10T18:48:58Z-
dc.date.available2023-10-10T18:48:58Z-
dc.date.issued2021-04-20-
dc.identifier.citationFERNANDES, Geraldo Magela et. al. Pregnancy outcomes and child development effects of SARS-CoV-2 Infection (PROUDEST Trial): protocol for a multicenter, prospective cohort study. JMIR Res Protoc., [s.l.], v. 10, n. 4, e26477, 2021. DOI: https://doi.org/10.2196%2F26477. Disponível em: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8059788/. Acesso em: 10 out. 2023.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/46658-
dc.language.isoengpt_BR
dc.rightsAcesso Abertopt_BR
dc.titlePregnancy outcomes and child development effects of SARS-CoV-2 Infection (PROUDEST Trial) : protocol for a multicenter, prospective cohort studypt_BR
dc.typeArtigopt_BR
dc.subject.keywordSARS-CoV-2pt_BR
dc.subject.keywordDesenvolvimento infantilpt_BR
dc.subject.keywordDesenvolvimento embrionáriopt_BR
dc.subject.keywordGravidezpt_BR
dc.rights.licenseThis is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Research Protocols, is properly cited. The complete bibliographic information, a link to the original publication on http://www.researchprotocols.org, as well as this copyright and license information must be included.pt_BR
dc.identifier.doihttps://doi.org/10.2196%2F26477pt_BR
dc.description.abstract1Background: A growing body of evidence suggests that SARS-COV-2 infection during pregnancy may affect maternal-fetal outcomes and possibly result in implications for the long-term development of SARSCoV-2–exposed children. Objective: The PROUDEST (Pregnancy Outcomes and Child Development Effects of SARS-CoV-2 Infection Study) is a multicenter, prospective cohort study designed to elucidate the repercussions of COVID19 for the global health of mothers and their children. Methods: The PROUDEST trial comprises 2 prospective, sequential substudies. The PREGNANT substudy will clinically assess the effects of SARS-CoV-2 infection on pregnancy, childbirth, and puerperium from a mechanistic standpoint to elucidate the pregnancy-related inflammatory and immunological phenomena underlying COVID-19. Pregnant women aged 18-40 years who have been exposed (proven with laboratory tests) to SARS-CoV-2 (group A; n=300) will be compared to control subjects with no laboratory evidence of in-pregnancy exposure to the virus (group B; n=300). Subjects exposed to other infections during pregnancy will be excluded. The BORN substudy is a long-term follow-up study that will assess the offspring of women who enrolled in the prior substudy. It will describe the effects of SARS-CoV-2 exposure during pregnancy on children’s growth, neurodevelopment, and metabolism from birth up to 5 years of age. It includes two comparison groups; group A (exposed; n=300) comprises children born from SARS-CoV-2– exposed pregnancies, and group B (controls; n=300) comprises children born from nonexposed mothers. Results: Recruitment began in July 2020, and as of January 2021, 260 pregnant women who were infected with SARS-CoV-2 during pregnancy and 160 newborns have been included in the study. Data analysis is scheduled to start after all data are collected. Conclusions: Upon completion of the study, we expect to have comprehensive data that will provide a better understanding of the effects of SARS-CoV-2 infection and related inflammatory and immunological processes on pregnancy, puerperium, and infancy. Our findings will inform clinical decisions regarding the care of SARS-CoV-2–exposed mothers and children and support the development of evidence-based public health policies.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4347-8886pt_BR
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dc.identifier.orcidhttps://orcid.org/0000-0002-3095-971Xpt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8727-8328pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5759-2727pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8492-1605pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1751-8506pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-5371-5486pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-9166-1837pt_BR
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dc.identifier.orcidhttps://orcid.org/0000-0002-9245-7504pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-8182-5121pt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity Hospital of Brasília, Department of Rheumatologypt_BR
dc.contributor.affiliationState Health Department of the Federal Districtpt_BR
dc.contributor.affiliationUniversity Hospital of Brasília, Department of Rheumatologypt_BR
dc.contributor.affiliationUniversity Center of Brasília, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicinept_BR
dc.contributor.affiliationCentral Laboratory of Public Health of the Federal Districtpt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity Hospital of Brasília, Department of Rheumatologypt_BR
dc.contributor.affiliationUniversity Hospital of Brasília, Department of Rheumatologypt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity Hospital of Brasília, Department of Rheumatologypt_BR
dc.contributor.affiliationUniversity Hospital of Brasília, Department of Rheumatologypt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity Hospital of Brasília, Department of Rheumatologypt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicinept_BR
dc.contributor.affiliationUniversity Hospital of Brasília, Department of Rheumatologypt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicinept_BR
dc.description.unidadeFaculdade de Medicina (FMD)pt_BR
dc.description.unidadeFaculdade UnB Ceilândia (FCE)pt_BR
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