http://repositorio.unb.br/handle/10482/46665
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Título: | BAX gene (−248 G > A) polymorphism in a sample of patients diagnosed with thyroid cancer in the Federal District, Brazil |
Autor(es): | Duarte, Ligia C. A. Cardoso Fratelli, Caroline Ferreira Pereira, Alexandre Sampaio Rodrigues Souza, Jéssica Nayane Gomes de Freitas, Renata de Souza Morais, Rafael Martins de Barra Sobrinho, Alaor Silva, Calliandra Maria de Souza Oliveira, Jamila Reis de Oliveira, Diêgo Madureira de Silva, Izabel Cristina Rodrigues da |
ORCID: | https://orcid.org/0000-0002-9335-999X https://orcid.org/0000-0002-0511-9452 https://orcid.org/0000-0002-9064-0735 https://orcid.org/0000-0002-9577-0344 https://orcid.org/0000-0002-6836-3583 |
Afiliação do autor: | Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde Centro Universitário do Distrito Federal Hospital Sírio-Libanês, Brasília Imagens Médicas de Brasília (IMEB) Universidade de Brasília Universidade de Brasília Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde Universidade de Brasília, Programa de Pós-graduação em Ciências e Tecnologias em Saúde |
Assunto: | Polimorfismo (Genética) Tireóide - câncer |
Data de publicação: | 2021 |
Editora: | Sage |
Referência: | DUARTE, Ligia C. A. Cardoso et al. BAX gene (−248 G > A) polymorphism in a sample of patients diagnosed with thyroid cancer in the Federal District, Brazil. The International Journal of Biological Markers, v. 36, n. 4, 2021. DOI: https://doi.org/10.1177/17246008211057576. Disponível em: https://journals.sagepub.com/doi/full/10.1177/17246008211057576. Acesso em: 11 out. 2023. |
Resumo: | Introduction: Papillary thyroid cancer corresponds to approximately 1% of all carcinomas; nevertheless, it is the most prevalent endocrine neoplasm in the world. Studies reveal that the BAX (−248 G > A) polymorphism may be associated with negative regulation of BAX gene transcription activity, causing a decrease in its protein expression. Objective: The present study aimed to describe the genotype and allele frequencies of BAX single nucleotide polymorphisms (−248 G > A) (rs4645878) in the research patients, and to associate its presence with susceptibility to papillary thyroid cancer. Methods: This case-control study was conducted with 30 patients with papillary thyroid cancer. For the evaluation of genetic polymorphisms, the polymerase chain reaction-restriction fragment length polymorphism technique was employed. Allele and genotype frequencies were estimated using the SPSS program, and significant associations were considered when p < 0.05. Results: There was a significant genotypic difference between papillary thyroid cancer and the control group (p = 0.042). The GG genotype provided a protective factor for papillary thyroid cancer (p = 0.012, odds ratio (OR) = 0.313; confidence inter- val (CI) = 0.123–0.794). Likewise the G allele was a protective factor for papillary thyroid cancer (p = 0.009; OR = 0.360; CI = 0.163–0.793). The BAX gene polymorphism (−248 G > A) was associated with papillary thyroid cancer. Conclusion: BAX (−248 G > A) GG genotype carriers, or at least one mutated allele, was associated with papillary thyroid cancer in the Brazilian population studied, and the G allele presence is considered a protective factor against papillary thyroid cancer occurrence. |
Unidade Acadêmica: | Faculdade UnB Ceilândia (FCE) |
Programa de pós-graduação: | Programa de Pós-Graduação em Ciências e Tecnologias em Saúde |
Licença: | Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
DOI: | https://doi.org/10.1177/17246008211057576 |
Aparece nas coleções: | Artigos publicados em periódicos e afins |
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