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Universidade de Brasília
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dc.contributor.authorCavalcante, Cássia de Queiroz Oliveira-
dc.contributor.authorArcanjo, Daniel da Silva-
dc.contributor.authorSilva, Guilherme Guimarães da-
dc.contributor.authorOliveira, Diêgo Madureira de-
dc.contributor.authorGatto, Claudia Cristina-
dc.date.accessioned2023-10-24T13:26:41Z-
dc.date.available2023-10-24T13:26:41Z-
dc.date.issued2019-07-01-
dc.identifier.citationCAVALCANTE, Cássia de Q. O. Solution and solid behavior of mono and binuclear zinc(II) and nickel(II) complexes with dithiocarbazates: X-ray analysis, mass spectrometry and cytotoxicity against cancer cell lines. New Journal of Chemistry,, n. 28, 43, 11209-11221, 2019. DOI: 10.1039/c9nj01814j rsc.li/njc.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/46722-
dc.language.isoengpt_BR
dc.publisherThe Royal Society of Chemistry and the Centre National de la Recherche Scientifiquept_BR
dc.rightsAcesso Restritopt_BR
dc.titleSolution and solid behavior of mono and binuclear zinc(II) and nickel(II) complexes with dithiocarbazates : X-ray analysis, mass spectrometry and cytotoxicity against cancer cell linespt_BR
dc.typeArtigopt_BR
dc.subject.keywordDitiocarbazatospt_BR
dc.subject.keywordRaios Xpt_BR
dc.subject.keywordEspectrometria de massapt_BR
dc.subject.keywordCitotoxicidadept_BR
dc.subject.keywordCâncerpt_BR
dc.identifier.doi10.1039/c9nj01814j rsc.li/njcpt_BR
dc.relation.publisherversionhttps://pubs.rsc.org/en/content/articlelanding/2019/nj/c9nj01814jpt_BR
dc.description.abstract1The current work reports the synthesis and investigation by physical-chemistry and spectroscopic methods of three dithiocarbazates (2-acetylpyridine-S-allyl-dithiocarbazate – HL1 ; 2-acetylpyridine-S-p-bromobenzyl-dithiocarbazate – HL2 ; and 2-acetylpyridine-S-p-nitrobenzyl-dithiocarbazate – HL3) and six novel metal complexes derived from these Schiff-bases. Four crystal structures of the complexes are reported. The single crystal X-ray study showed two binuclear zinc(II) complexes with symmetrical and asymmetrical acetate bridges resulting in different coordination spheres. Another zinc(II) complex and three nickel(II) complexes present dithiocarbazates tridentate with NNS-donor atoms and octahedral geometry to the metal centers. The mass spectrometry data indicated the presence of the molecular ions [M + H]+ and characteristic fragments of the compounds. All characterization indicated the same behavior of the compounds as a solid and in solution. The biological activity of the zinc(II) and nickel(II) salts, the free dithiocarbazate ligands and their metal complexes was evaluated by assays with carcinoma mammary MDA-MB-231 cells. The results revealed that the free dithiocarbazates present great in vitro antitumor activity, which is increased after the complexation with zinc, with emphasis on the dimeric complex (1), which had an IC50 of 2.0 mM and exhibits more potential inhibition of tumor cell growth than the nickel(II) complexes.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-6044-1954pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3736-6861pt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Chemistry, Laboratory of Inorganic Synthesis and Crystallographypt_BR
dc.contributor.affiliationUniversity of Brasília, Laboratory of Cancerpt_BR
dc.contributor.affiliationUniversity of Brasília, Laboratory of Cancerpt_BR
dc.contributor.affiliationUniversity of Brasília, Laboratory of Cancerpt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Chemistry, Laboratory of Inorganic Synthesis and Crystallographypt_BR
dc.description.unidadeInstituto de Química (IQ)pt_BR
dc.description.unidadeFaculdade UnB Ceilândia (FCE)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências e Tecnologias em Saúdept_BR
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