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dc.contributor.authorAraújo, Joabe Lima-
dc.contributor.authorSilva, Patrícia Bento da-
dc.contributor.authorSantos, Bruno Fonseca-
dc.contributor.authorBáo, Sônia Nair-
dc.contributor.authorChorilli, Marlus-
dc.contributor.authorSouza, Paulo Eduardo Narcizo de-
dc.contributor.authorMuehlmann, Luis Alexandre-
dc.contributor.authorAzevedo, Ricardo Bentes-
dc.date.accessioned2023-12-12T10:40:02Z-
dc.date.available2023-12-12T10:40:02Z-
dc.date.issued2023-11-29-
dc.identifier.citationARAÚJO, Joabe Lima et al. Photodynamic therapy directed to melanoma skin cancer by thermosensitive hydrogel containing Chlorophyll A. Pharmaceuticals, [S. l.], v. 16, n. 12, 1659, 2023. DOI: https://doi.org/10.3390/ph16121659.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/46974-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titlePhotodynamic therapy directed to melanoma skin cancer by thermosensitive hydrogel containing Chlorophyll Apt_BR
dc.typeArtigopt_BR
dc.subject.keywordTerapia fotodinâmicapt_BR
dc.subject.keywordMelanomapt_BR
dc.subject.keywordPele - câncerpt_BR
dc.subject.keywordHidrogelpt_BR
dc.rights.licenseCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/ph16121659pt_BR
dc.description.abstract1Melanoma, a severe form of skin cancer intricately linked to genetic and environmental factors, is predicted to reach 100,000 new cases worldwide by 2040, underscoring the need for effective and safe treatment options. In this study, we assessed the efficacy of a photosensitizer called Chlorophyll A (Chl-A) incorporated into hydrogels (HGs) made of chitosan (CS) and poloxamer 407 (P407) for Photodynamic Therapy (PDT) against the murine melanoma cell line B16-F10. The HG was evaluated through various tests, including rheological studies, SEM, and ATR-FTIR, along with cell viability assays. The CS- and P407-based HGs effectively released Chl-A and possessed the necessary properties for topical application. The photodynamic activity of the HG containing Chl-A was evaluated in vitro, demonstrating high therapeutic potential, with an IC50 of 25.99 µM—an appealing result when compared to studies in the literature reporting an IC50 of 173.8 µM for cisplatin, used as a positive control drug. The developed formulation of CS and P407-based HG, serving as a thermosensitive system for topical applications, successfully controlled the release of Chl-A. In vitro cell studies associated with PDT exhibited potential against the melanoma cell line.pt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Genetics and Morphologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Genetics and Morphologypt_BR
dc.contributor.affiliationFederal University of Bahia, Health Sciences Institute, Department of Biotechnologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Cellular Biology Departmentpt_BR
dc.contributor.affiliationSão Paulo State University, School of Pharmaceutical Sciences, Araraquarapt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Physicspt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilandiapt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Genetics and Morphologypt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Genética e Morfologia (IB GEM)pt_BR
dc.description.unidadeDepartamento de Biologia Celular (IB CEL)pt_BR
dc.description.unidadeInstituto de Física (IF)pt_BR
dc.description.unidadeFaculdade UnB Ceilândia (FCE)pt_BR
dc.description.unidadeColegiado de Bases Biológicas e da Saúde (FCE-BASES)pt_BR
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