Título:	Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats : impact on inflammatory response, lipid profile, and gut microbiota
Autor(es):	Cavalcanti, Marilia Hermes Roseira, João Paulo Santos Leandro, Eliana dos Santos Arruda, Sandra Fernandes
ORCID:	https://orcid.org/0000-0002-9826-6004
Afiliação do autor:	Universidade de Brasília, Faculty of Health Sciences, Postgraduate Program in Human Nutrition Universidade Federal de Viçosa, Department of Animal Science Universidade de Brasília, Faculty of Health Sciences, Postgraduate Program in Human Nutrition Universidade de Brasília, Faculty of Health Sciences, Postgraduate Program in Human Nutrition
Assunto:	Dietas Café Bile Bifidobactérias Escherichia coli Obesidade Lactobacilos
Data de publicação:	26-Jan-2022
Editora:	Plos
Referência:	CAVALCANTI, Marilia Hermes et al. Effect of a freeze-dried coffee solution in a high-fat diet-induced obesity model in rats: impact on inflammatory response, lipid profile, and gut microbiota. PLoS ONE, [S. l.], v. 17, n. 1, e0262270, 2022. DOI: https://doi.org/10.1371/journal.pone.0262270. Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0262270. Acesso em: 05 jan. 2024.
Abstract:	Coffee beans contain high polyphenol content, which have the potential to modulate the intestinal microbiota, and possibly attenuate weight gain and the associated dyslipidemia. This study investigated the effect of freeze-dried coffee solution (FCS) consumption on physiological parameters, lipid profile, and microbiota of Wistar rats fed a high-fat diet (HF) or control diet (CT). FCS combined with a high-fat diet increased the fecal and cecal Bifidobacterium spp. population and decreased the cecal Escherichia coli population and intestinal Il1b mRNA level. Regardless of the diet type, FCS increased the serum high-density lipoprotein cholesterol (HDL-C); however, it did not affect body weight, food intake, low-density lipoprotein, triglycerides, fecal bile acids, and intestinal Il6 mRNA levels. The high-fat diet increased weight gain, hepatic cholesterol and triglycerides, fecal bile acids, and the fecal and cecal Lactobacillus spp. population, and reduced food intake, the fecal E. coli population, and intestinal Il6 mRNA level. The results suggest that FCS consumption exhibits positive health effects in rats fed a high-fat diet by increasing Bifidobacterium spp. population and HDL-C reverse cholesterol transport, and by reducing Il1b mRNA level. However, FCS administration at a dose of 0.39 g/100 g diet over an eight-week period was not effective in controlling food intake, and consequently, preventing weight gain in rats of high-fat diet-induced obesity model.
Unidade Acadêmica:	Faculdade de Ciências da Saúde (FS) Departamento de Nutrição (FS NUT)
Programa de pós-graduação:	Programa de Pós-Graduação em Nutrição Humana
Licença:	© 2022 Cavalcanti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI:	https://doi.org/10.1371/journal.pone.0262270
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