| Campo DC | Valor | Lengua/Idioma |
|---|
| dc.contributor.author | Rodrigues, Marina Lima | - |
| dc.contributor.author | Gomes, Anderson de Jesus | - |
| dc.contributor.author | Funez, Mani Indiana | - |
| dc.contributor.author | Marques, Mariane Aparecida da Silva | - |
| dc.contributor.author | Lunardi, Claure Nain | - |
| dc.date.accessioned | 2024-02-01T14:39:23Z | - |
| dc.date.available | 2024-02-01T14:39:23Z | - |
| dc.date.issued | 2022-11-29 | - |
| dc.identifier.citation | RODRIGUES, Marina Lima et al. Euphorbia tirucalli latex loaded polymer nanoparticles: synthesis, characterization, in vitro release and in vivo antinociceptive action. Plos One, [S. l.], v. 17, n. 11, e0274432, 2022. DOI: https://doi.org/10.1371/journal.pone.0274432.Disponível em: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0274432. Acesso em: 01 fev. 2024. | pt_BR |
| dc.identifier.uri | http://repositorio2.unb.br/jspui/handle/10482/47632 | - |
| dc.language.iso | eng | pt_BR |
| dc.publisher | Plos One | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.title | Euphorbia tirucalli latex loaded polymer nanoparticles : synthesis, characterization, in vitro release and in vivo antinociceptive action | pt_BR |
| dc.type | Artigo | pt_BR |
| dc.subject.keyword | Nanopartículas | pt_BR |
| dc.subject.keyword | Medicamentos | pt_BR |
| dc.subject.keyword | Látex | pt_BR |
| dc.rights.license | Copyright: © 2022 Rodrigues et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | pt_BR |
| dc.identifier.doi | https://doi.org/10.1371/journal.pone.0274432 | pt_BR |
| dc.description.abstract1 | The encapsulation of drugs in micro and nanocarriers has helped to resolve mechanisms of
cellular resistance and decrease drug side effects as well. In this study, poly(D,L-lactide-co glycolide) (PLGA) was used to encapsulate the Euphol active substance-containing latex
from Euphorbia tirucalli (E-latex). The nanoparticles (NP) were prepared using the solvent
evaporation method and the physical and chemical properties were evaluated using spec trophotometric techniques. FTIR was used to prove the formation of the ester bond between
the E-latex and PLGA-NP. The UV-Vis spectroscopic technique was used to show that
more than 75% of the latex was encapsulated; the same technique was used to determine
the release profile of the compound at different pH values, as well as determining the speed
with which the process occurs through kinetic models, and it was observed that the best
adjustments occurred for the Korsmeyer-Peppas model and the Higuchi model. The DLS
technique was used to determine the diameter of the particles produced as well as their zeta
potential (ZP). The sizes of the particles varied from 497 to 764 nm, and it was observed
that the increase in E-latex concentration causes a reduction in the diameter of the NP and
an increase in the ZP (-1.44 to -22.7 mV), due to more functional groups from latex film
being adsorbed to the NPs surfaces. The thermogravimetric experiments exhibit the glass
transition temperatures (Tg) that is appropriate for the use of formulated NPs as a stable
drug delivery device before use. The in vivo activity of E-NPs (30 and 100 mg/Kg/p.o.) was
tested against carrageenan-induced mechanical hypernociception. The data demonstrated
a significantly antinociceptive effect for E-NPs, suggesting that E-latex nanoencapsulation
preserved its desired properties. | pt_BR |
| dc.identifier.orcid | https://orcid.org/0000-0001-8712-4417 | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Campus Ceilandia, Laboratory of Photochemistry and Nanobiotechnology | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Program in Nanoscience and Nanobiotechnology | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Campus Ceilandia, Laboratory of Photochemistry and Nanobiotechnology | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Program in Nanoscience and Nanobiotechnology | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Campus Ceilandia, Sciences and Technologies in Health Program | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Campus Ceilandia, Sciences and Technologies in Health Program | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Campus Ceilandia, Sciences and Technologies in Health Program | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Campus Ceilandia, Laboratory of Photochemistry and Nanobiotechnology | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Program in Nanoscience and Nanobiotechnology | pt_BR |
| dc.contributor.affiliation | University of Brasilia, Campus Ceilandia, Laboratory of Photochemistry and Nanobiotechnology | pt_BR |
| dc.description.unidade | Faculdade UnB Ceilândia (FCE) | pt_BR |
| dc.description.unidade | Colegiado de Bases Biológicas e da Saúde (FCE-BASES) | pt_BR |
| dc.description.unidade | Instituto de Ciências Biológicas (IB) | pt_BR |
| dc.description.ppg | Programa de Pós-Graduação em Nanociência e Nanobiotecnologia | pt_BR |
| dc.description.ppg | Programa de Pós-Graduação em Ciências e Tecnologias em Saúde | pt_BR |
| Aparece en las colecciones: | Artigos publicados em periódicos e afins
|
