Skip navigation
Use este identificador para citar ou linkar para este item: http://repositorio2.unb.br/jspui/handle/10482/47633
Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
ARTIGO_In-situFormationNanoparticles.pdf4,67 MBAdobe PDFVisualizar/Abrir
Registro completo de metadados
Campo DCValorIdioma
dc.contributor.authorPires, Felipe Queiroz-
dc.contributor.authorGross, Idejan Padilha-
dc.contributor.authorBarreto, Livia Cristina Lira de Sá-
dc.contributor.authorGratieri, Taís-
dc.contributor.authorGelfuso, Guilherme Martins-
dc.contributor.authorBáo, Sônia Nair-
dc.contributor.authorCunha Filho, Marcílio Sérgio Soares da-
dc.date.accessioned2024-02-01T15:21:57Z-
dc.date.available2024-02-01T15:21:57Z-
dc.date.issued2023-07-03-
dc.identifier.citationPIRES, Felipe Q. et al. In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices. European Journal of Pharmaceutical Sciences, v. 188,106517, 1 set. 2023. DOI: https://doi.org/10.1016/j.ejps.2023.106517. Disponível em: https://www.sciencedirect.com/science/article/pii/S0928098723001471?via%3Dihub. Acesso em: 02 fev. 2024.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/47633-
dc.language.isoengpt_BR
dc.publisherElsevier B.V.pt_BR
dc.rightsAcesso Abertopt_BR
dc.titleIn-situ formation of nanoparticles from drug-loaded 3D polymeric matricespt_BR
dc.typeArtigopt_BR
dc.subject.keywordNaringeninapt_BR
dc.subject.keywordNanopartículaspt_BR
dc.subject.keywordMedicamentospt_BR
dc.rights.licenseThis is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ejps.2023.106517pt_BR
dc.description.abstract1The in-situ formation of nanoparticles from polymer-based solid medicines, although previously described, has been overlooked despite its potential to interfere with oral drug bioavailability. Such polymeric pharmaceuticals are becoming increasingly common on the market and can become even more popular due to the dizzying advance of 3D printing medicines. Hence, this work aimed to study this phenomenon during the dissolution of 3D printed tablets produced with three different polymers, hydroxypropylmethylcellulose acetate succinate (HPMCAS), polyvinyl alcohol (PVA), and Eudragit RL PO® (EUD RL) combined with plasticizers and the model drug naringenin (NAR). The components’ interaction, dissolution behavior, and characteristics of the formed particles were investigated employing thermal, spectroscopic, mechanical, and chromatographic assays. All the systems generated stable spherical-shaped particles throughout 24 h, encapsulating over 25% of NAR. Results suggest encapsulation efficiencies variations may depend on interactions between polymer-drug, drug-plasti cizer, and polymer-plasticizer, which formed stable nanoparticles even in the drug absence, as observed with the HPMCAS and EUD RL formulations. Additionally, components solubility in the medium and previous formulation treatments are also a decisive factor for nanoparticle formation. In particular, the treatment provided by hot-melt extrusion and FDM 3D printing affected the dissolution efficiency enhancing the interaction between the com ponents, reverberating on particle size and particle formation kinetics mainly for HPMCAS and EUD RL. In conclusion, the 3D printing process influences the in-situ formation of nanoparticles, which can directly affect oral drug bioavailability and needs to be monitored.pt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Ceilandiapt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmeticspt_BR
dc.contributor.affiliationUniversity of Brasilia, Institute of Biological Sciences, Laboratório de Microscopia e Microanálisept_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmeticspt_BR
dc.description.unidadeFaculdade UnB Ceilândia (FCE)pt_BR
dc.description.unidadeCurso de Farmácia (FCE-FAR)pt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Biologia Celular (IB CEL)pt_BR
Aparece nas coleções:Artigos publicados em periódicos e afins

Mostrar registro simples do item Visualizar estatísticas



Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.