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Universidade de Brasília
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dc.contributor.authorMayer, Andréia Biolchi-
dc.contributor.authorAmaral, Henrique de Oliveira-
dc.contributor.authorOliveira, Danilo Gustavo R. de-
dc.contributor.authorCampos, Gabriel Avohay Alves-
dc.contributor.authorRibeiro, Priscilla Galante-
dc.contributor.authorFernandes, Solange Cristina Rego-
dc.contributor.authorSouza, Adolfo Carlos Barros de-
dc.contributor.authorCastro, Raffael Júnio Araújo de-
dc.contributor.authorBocca, Anamélia Lorenzetti-
dc.contributor.authorMortari, Márcia Renata-
dc.date.accessioned2024-02-02T13:05:16Z-
dc.date.available2024-02-02T13:05:16Z-
dc.date.issued2023-11-
dc.identifier.citationMAYER, Andréia Biolchi et al. New fraternine analogues: evaluation of the antiparkinsonian effect in the model of Parkinson’s disease. Neuropeptides, [S. l.], v. 103, 102390, fev. 2024. DOI: https://doi.org/10.1016/j.npep.2023.102390.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/47668-
dc.language.isoengpt_BR
dc.publisherElsevier Ltd.pt_BR
dc.rightsAcesso Restritopt_BR
dc.titleNew fraternine analogues : evaluation of the antiparkinsonian effect in the model of Parkinson’s diseasept_BR
dc.typeArtigopt_BR
dc.subject.keywordParkinson, Doença de - tratamentopt_BR
dc.subject.keywordPeptídeos sintéticospt_BR
dc.subject.keywordVespa - venenopt_BR
dc.subject.keywordMedicamentospt_BR
dc.subject.keywordCoordenação motorapt_BR
dc.identifier.doihttps://doi.org/10.1016/j.npep.2023.102390pt_BR
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0143417923000719pt_BR
dc.description.abstract1Venom-derived peptides are important sources for the development of new therapeutic molecules, especially due to their broad pharmacological activity. Previously, our research group identified a novel natural peptide, named fraternine, with promising effects for the treatment of Parkinson's disease. In the present paper, we synthesized three peptides bioinspired in fraternine: fra-10, fra-14, and fra-24. They were tested in the 6-OHDA-induced model of parkinsonism, quantifying motor coordination, levels of TH+ neurons in the substantia nigra pars compacta (SN), and inflammation mediators TNF-α, IL-6, and IL-1ß in the cortex. Peptides fra-14 and fra-10 improved the motor coordination in relation to 6-OHDA lesioned animals. However, most of the peptides were toxic in the doses applied. All three peptides reduced the intensity of the lesion induced rotations in the apomorphine test. Fra-24 higher dose increased the number of TH+ neurons in SN and reduced the concentration of TNF-α in the cortex of 6-OHDA lesioned mice. Overall, only the peptide fra-24 presented a neuroprotection effect on dopaminergic neurons of SN and a reduction of cytokine TNF-α levels, making it worthy of consideration for the treatment of PD.pt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationUniversity of Brasília,Institute of Biological Sciences, Department of Cellular Biology, Laboratory of Applied Immunologypt_BR
dc.contributor.affiliationUniversity of Brasília,Institute of Biological Sciences, Department of Cellular Biology, Laboratory of Applied Immunologypt_BR
dc.contributor.affiliationUniversity of Brasília, Institute of Biological Sciences, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Ciências Fisiológicas (IB CFS)pt_BR
dc.description.unidadeDepartamento de Biologia Celular (IB CEL)pt_BR
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