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dc.contributor.authorVilela, Wembley Rodrigues-
dc.contributor.authorBellozi, Paula Maria Quaglio-
dc.contributor.authorPicolo, Victor Luna-
dc.contributor.authorCavadas, Bruna Neves-
dc.contributor.authorMarques, Keila Valentina Silva-
dc.contributor.authorPereira, Louise Tavares Garcia-
dc.contributor.authorGuirao, Ainhoa Rodriguez de Yurre-
dc.contributor.authorAmato, Angélica Amorim-
dc.contributor.authorMagalhães, Kelly Grace-
dc.contributor.authorMortari, Márcia Renata-
dc.contributor.authorMedei, Emiliano Horacio-
dc.contributor.authorGoulart, Jair Trapé-
dc.contributor.authorBem, Andreza Fabro de-
dc.date.accessioned2024-02-19T14:37:08Z-
dc.date.available2024-02-19T14:37:08Z-
dc.date.issued2023-
dc.identifier.citationVILELA, Wembley Rodrigues et al. Early-life metabolic dysfunction impairs cognition and mitochondrial function in mice. The Journal of Nutritional Biochemistry, v. 117, 109352, jul. 2023. DOI: https://doi.org/10.1016/j.jnutbio.2023.109352.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/47780-
dc.language.isoengpt_BR
dc.publisherElsevier Inc.pt_BR
dc.rightsAcesso Restritopt_BR
dc.titleEarly-life metabolic dysfunction impairs cognition and mitochondrial function in micept_BR
dc.typeArtigopt_BR
dc.subject.keywordDieta hiperlipídicapt_BR
dc.subject.keywordEstreptozotocinapt_BR
dc.subject.keywordMitocôndriapt_BR
dc.subject.keywordHipocampopt_BR
dc.subject.keywordTecido adiposo marrompt_BR
dc.subject.keywordCogniçãopt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jnutbio.2023.109352pt_BR
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0955286323000852?via%3Dihubpt_BR
dc.description.abstract1The impact of overnutrition early in life is not restricted to the onset of cardiovascular and metabolic diseases, but also affects critical brain functions related to cognition. This study aimed to evaluate the relationship between peripheral metabolic and bioenergetic changes induced by a two-hit protocol and their impact on cognitive function in juvenile mice. Three-week-old male C57BL/6 mice received a high-fat diet (HFD) or control diet for 7 weeks, as sociated with two low doses of streptozotocin (STZ) or vehicle. Despite the absence of obesity, HFD+STZ impaired glucose metabolism and induced a trend towards cholesterol increase. The two-hit protocol impaired recognition and spatial memories in juvenile mice, without inducing a depressive-like behavior. HFD+STZ mice presented increased immunoreactivity for GFAP and a trend towards a decrease in NeuN in the hippocampus. The treatment caused a bioen ergetic impairment in the hippocampus, characterized by a decrease in both O2 consumption related to ATP production and in the maximum respiratory capacity. The thermogenic capacity of brown adipose tissue was impaired by the two-hit protocol, here verified through the absence of a decrease in O2 consumption after uncoupled protein-1 inhibition and an increase in the reserve respiratory capacity. Impaired mitochondrial function was also observed in the liver of HFD+STZ juvenile mice, but not in their heart. These results indicate that exposure to HFD+STZ early in life has a detrimental impact on the bioenergetic and mitochondrial function of tissues with metabolic and thermogenic activities, which is likely related to hippocampal metabolic changes and cognitive impairment.pt_BR
dc.contributor.affiliationUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Bioenergetics and Metabolismpt_BR
dc.contributor.affiliationUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Bioenergetics and Metabolismpt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Laboratory of Molecular Pharmacologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Bioenergetics and Metabolismpt_BR
dc.contributor.affiliationUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Bioenergetics and Metabolismpt_BR
dc.contributor.affiliationUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Bioenergetics and Metabolismpt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Laboratory of Molecular Pharmacologypt_BR
dc.contributor.affiliationFederal University of Rio de Janeiro, Carlos Chagas Filho Institute of Biophysics, Laboratory of Cardioimunologypt_BR
dc.contributor.affiliationUniversity of Brasilia, School of Health Sciences, Laboratory of Molecular Pharmacologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Immunology and Inflammationpt_BR
dc.contributor.affiliationUniversity of Brasilia,Biology Institute, Department of Physiological Sciences, Laboratory of Neuropharmacologypt_BR
dc.contributor.affiliationFederal University of Rio de Janeiro, Carlos Chagas Filho Institute of Biophysics, Laboratory of Cardioimunologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Bioenergetics and Metabolismpt_BR
dc.contributor.affiliationUniversity of Brasilia, Biology Institute, Department of Physiological Sciences, Laboratory of Bioenergetics and Metabolismpt_BR
dc.contributor.affiliationUniversity of Brasiliapt_BR
dc.description.unidadeInstituto de Ciências Biológicas (IB)pt_BR
dc.description.unidadeDepartamento de Ciências Fisiológicas (IB CFS)pt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
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