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dc.contributor.authorÇiçek, Serhat Sezai-
dc.contributor.authorBarbosa, Anna Laís Pfeifer-
dc.contributor.authorWenzel-Storjohann, Arlette-
dc.contributor.authorSegovia, Jorge Federico Orellana-
dc.contributor.authorBezerra, Roberto Messias-
dc.contributor.authorSönnichsen, Frank-
dc.contributor.authorZidorn, Christian-
dc.contributor.authorKanzaki, Isamu-
dc.contributor.authorTasdemir, Deniz-
dc.date.accessioned2024-03-25T12:10:37Z-
dc.date.available2024-03-25T12:10:37Z-
dc.date.issued2022-12-25-
dc.identifier.citationÇIÇEK, Serhat Seai et al. Chemical and biological evaluation of amazonian medicinal plant vouacapoua americana aubl. Plants, [S.l.], v. 12, n. 99, 25 dez 2022. Disponível em: https://doi.org/10.3390/plants12010099. Acesso em: 20 mar 2024.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/48026-
dc.language.isoengpt_BR
dc.publisherMDPIpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleChemical and biological evaluation of amazonian medicinal plant vouacapoua americana aublpt_BR
dc.typeArtigopt_BR
dc.subject.keywordAntimicrobianopt_BR
dc.subject.keywordAcapupt_BR
dc.subject.keywordPlantas medicinaispt_BR
dc.rights.license© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).pt_BR
dc.identifier.doihttps://doi.org/10.3390/plants12010099pt_BR
dc.description.abstract1Vouacapoua americana (Fabaceae) is an economically important tree in the Amazon region and used for its highly resistant heartwood as well as for medicinal purposes. Despite its frequent use, phytochemical investigations have been limited and rather focused on ecological properties than on its pharmacological potential. In this study, we investigated the phytochemistry and bioactivity of V. americana stem bark extract and its constituents to identify eventual lead structures for further drug development. Applying hydrodistillation and subsequent GC-MS analysis, we investigated the composition of the essential oil and identified the 15 most abundant components. Moreover, the diterpenoids deacetylchagresnone (1), cassa-13(14),15-dien-oic acid (2), isoneocaesalpin H (3), (+)-vouacapenic acid (4), and (+)-methyl vouacapenate (5) were isolated from the stem bark, with compounds 2 and 4 showing pronounced effects on Methicillin-resistant Staphylococcus aureus and Enterococcus faecium, respectively. During the structure elucidation of deacetylchagresnone (1), which was isolated from a natural source for the first time, we detected inconsistencies regarding the configuration of the cyclopropane ring. Thus, the structure was revised for both deacetylchagresnone (1) and the previously isolated chagresnone. Following our works on Copaifera reticulata and Vatairea guianensis, the results of this study further contribute to the knowledge of Amazonian medicinal plants.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3038-8523pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-4539-3755pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-8956-9874pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-7841-6271pt_BR
dc.contributor.affiliationKiel University, Department of Pharmaceutical Biologypt_BR
dc.contributor.affiliationKiel University, Department of Pharmaceutical Biologypt_BR
dc.contributor.affiliationGEOMAR Helmholtz Centre for Ocean Research Kiel, GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Products Chemistrypt_BR
dc.contributor.affiliationBrazilian Agricultural Research Corporation, Ecoregional Research Unitpt_BR
dc.contributor.affiliationFederal University of Amapá, Laboratory of Bioprospection and Atomic Absorptionpt_BR
dc.contributor.affiliationKiel University, Otto Diels Institute for Organic Chemistrypt_BR
dc.contributor.affiliationKiel University, Department of Pharmaceutical Biologypt_BR
dc.contributor.affiliationUniversity of Brasilia, Darcy Ribeiro Campus, Laboratory of Bioprospectionpt_BR
dc.contributor.affiliationGEOMAR Helmholtz Centre for Ocean Research Kiel, GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Products Chemistrypt_BR
dc.contributor.affiliationKiel University, Faculty of Mathematics and Natural Sciencespt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
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