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Use este identificador para citar ou linkar para este item: http://repositorio.unb.br/handle/10482/48134
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dc.contributor.authorOliveira, Andressa Souza de-
dc.contributor.authorOliveira, Jonathas Sales de-
dc.contributor.authorKumar, Rajender-
dc.contributor.authorSilva, Fabiana Brandão Alves-
dc.contributor.authorFernandes, Mirele Rodrigues-
dc.contributor.authorNobre, Feynman Dias-
dc.contributor.authorCosta, Anderson da Cunha-
dc.contributor.authorAlbuquerque, Patrícia-
dc.contributor.authorSidrim, José Júlio Costa-
dc.contributor.authorRocha, Marcos Fábio Gadelha-
dc.contributor.authorSantos, Flavia Almeida-
dc.contributor.authorSrivastava, Vaibhav-
dc.contributor.authorRomeiro, Luiz Antonio Soares-
dc.contributor.authorBrilhante, Raimunda Sâmia Nogueira-
dc.date.accessioned2024-05-28T12:04:22Z-
dc.date.available2024-05-28T12:04:22Z-
dc.date.issued2023-08-08-
dc.identifier.citationOLIVEIRA, Andressa Souza de et al. Antifungal activity of sustainable histone deacetylase inhibitors against planktonic cells and biofilms of Candida spp. and Cryptococcus neoformans. Medical Mycology, [S. l.], v. 61, n. 8, myad073, ago. 2023. DOI: https://doi.org/10.1093/mmy/myad073.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/48134-
dc.language.isoengpt_BR
dc.publisherOxford University Press on behalf of The International Society for Human and Animal Mycologypt_BR
dc.rightsAcesso Restritopt_BR
dc.titleAntifungal activity of sustainable histone deacetylase inhibitors against planktonic cells and biofilms of Candida spp. and Cryptococcus neoformanspt_BR
dc.typeArtigopt_BR
dc.subject.keywordAntifúngicospt_BR
dc.subject.keywordInibidores de histonas desacetilasespt_BR
dc.subject.keywordÁcido hidroxâmicopt_BR
dc.subject.keywordBiofilmept_BR
dc.identifier.doihttps://doi.org/10.1093/mmy/myad073pt_BR
dc.relation.publisherversionhttps://academic.oup.com/mmy/article/61/8/myad073/7239295pt_BR
dc.description.abstract1The limited therapeutic options for fungal infections and the increased incidence of fungal strains resistant to antifungal drugs, especially Candida spp., require the development of new antifungal drugs and strategies. Histone deacetylase inhibitors (HDACi), like vorinostat, have been studied in cancer treatment and have antifungal effects, acting alone or synergistically with classical antifungals. Here we investigated the antifungal activity of two novel sustainable HDACi (LDT compounds) based on vorinostat structure. Molecular docking simulation studies reveal that LDT compounds can bind to Class-I HDACs of Candida albicans, C. tropicalis, and Cryptococcus neoformans, which showed similar binding mode to vorinostat. LDT compounds showed moderate activity when tested alone against fungi but act synergistically with antifungal azoles against Candida spp. They reduced biofilm formation by more than 50% in C. albicans (4 μg/mL), with the main action in fungal filamentation. Cytotoxicity of the LDT compounds against RAW264.7 cells was evaluated and LDT536 demonstrated cytotoxicity only at the concentration of 200 μmol/L, while LDT537 showed IC50 values of 29.12 μmol/L. Our data indicated that these sustainable and inexpensive HDACi have potential antifungal and antibiofilm activities, with better results than vorinostat, although further studies are necessary to better understand the mechanism against fungal cells.pt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Medicine, Tropical Medicine Centre, Laboratory of Development of Therapeutic Innovationspt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Health Sciences, Postgraduate Program in Pharmaceutical Sciencespt_BR
dc.contributor.affiliationFederal University of Ceará, Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Centrept_BR
dc.contributor.affiliationAlbaNova University Center, KTH Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Chemistry, Division of Glycosciencept_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Medicine, Postgraduate Program in Tropical Medicinept_BR
dc.contributor.affiliationFederal University of Ceará, Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Centrept_BR
dc.contributor.affiliationFederal University of Ceará, Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Centrept_BR
dc.contributor.affiliationFederal University of Ceará, Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Centrept_BR
dc.contributor.affiliationUniversity of Brasília. Campus Ceilândiapt_BR
dc.contributor.affiliationFederal University of Ceará, Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Centrept_BR
dc.contributor.affiliationFederal University of Ceará, Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Centrept_BR
dc.contributor.affiliationFederal University of Ceará, Department of Physiology and Pharmacology, Laboratory of Natural Productspt_BR
dc.contributor.affiliationAlbaNova University Center, KTH Royal Institute of Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Chemistry, Division of Glycosciencept_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Medicine, Tropical Medicine Centre, Laboratory of Development of Therapeutic Innovationspt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Health Sciences, Postgraduate Program in Pharmaceutical Sciencespt_BR
dc.contributor.affiliationUniversity of Brasilia, Faculty of Medicine, Postgraduate Program in Tropical Medicinept_BR
dc.contributor.affiliationFederal University of Ceará, Department of Pathology and Legal Medicine, Postgraduate Program in Medical Microbiology, Specialized Medical Mycology Centrept_BR
dc.description.unidadeFaculdade de Medicina (FM)pt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
dc.description.ppgPrograma de Pós-Graduação em Ciências Farmacêuticaspt_BR
dc.description.ppgPrograma de Pós-Graduação em Medicina Tropicalpt_BR
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