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dc.contributor.authorLemes, Laís Flávia Nunes-
dc.contributor.authorMagoulas, George E.-
dc.contributor.authorOliveira, Andressa Souza de-
dc.contributor.authorBarrias, Emile-
dc.contributor.authorNascente, Luciana de Camargo-
dc.contributor.authorGranado, Renato-
dc.contributor.authorSilva, Sara Teixeira de Macedo-
dc.contributor.authorAssimomytis, Nikos-
dc.contributor.authorSouza, Wanderley de-
dc.contributor.authorBolognesi, Maria Laura-
dc.contributor.authorRomeiro, Luiz Antonio Soares-
dc.contributor.authorCalogeropoulou, Theodora-
dc.date.accessioned2024-06-05T15:06:39Z-
dc.date.available2024-06-05T15:06:39Z-
dc.date.issued2023-06-12-
dc.identifier.citationLEMES, Laís Flávia Nunes et al. Valorizing constituents of cashew nut shell liquid toward the sustainable development of new drugs against chagas disease. ACS Infectious Diseases, [S. l.], v. 9, n. 7, 1334-1345, 2023. DOI: https://doi.org/10.1021/acsinfecdis.3c00076.pt_BR
dc.identifier.urihttp://repositorio2.unb.br/jspui/handle/10482/48162-
dc.language.isoengpt_BR
dc.publisherAmerican Chemical Societypt_BR
dc.rightsAcesso Restritopt_BR
dc.titleValorizing constituents of cashew nut shell liquid toward the sustainable development of new drugs against chagas diseasept_BR
dc.typeArtigopt_BR
dc.subject.keywordCastanha de cajupt_BR
dc.subject.keywordAtividade antiparasitáriapt_BR
dc.subject.keywordTrypanosoma cruzipt_BR
dc.identifier.doihttps://doi.org/10.1021/acsinfecdis.3c00076pt_BR
dc.relation.publisherversionhttps://pubs.acs.org/doi/10.1021/acsinfecdis.3c00076?ref=PDF-
dc.description.abstract1Six new ether phospholipid analogues encompassing constituents from cashew nut shell liquid as the lipid portion were synthesized in an effort to valorize byproducts of the cashew industry toward the generation of potent compounds against Chagas disease. Anacardic acids, cardanols, and cardols were used as the lipid portions and choline as the polar headgroup. The compounds were evaluated for their in vitro antiparasitic activity against different developmental stages of Trypanosoma cruzi. Compounds 16 and 17 were found to be the most potent against T. cruzi epimastigotes, trypomastigotes, and intracellular amastigotes exhibiting selectivity indices against the latter 32-fold and 7-fold higher than current drug benznidazole, respectively. Hence, four out of six analogues can be considered as hit-compounds toward the sustainable development of new treatments for Chagas disease, based on inexpensive agro-waste material.pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-1289-5361pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0001-5679-0820pt_BR
dc.identifier.orcidhttps://orcid.org/0000-0002-3369-5393pt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Tropical Medicine Centerpt_BR
dc.contributor.affiliationNational Hellenic Research Foundation, Institute of Chemical Biologypt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Sciences, Department of Pharmacypt_BR
dc.contributor.affiliationUniversidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filhopt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Sciences, Department of Pharmacypt_BR
dc.contributor.affiliationNational Institute of Metrology, Quality and Technology - Inmetro, Laboratory of Metrology Applied to Life Sciencespt_BR
dc.contributor.affiliationUniversidade Federal do Rio de Janeiro, Centro Nacional de Biologia Estrutural e Bioimagem, Centro de Ciências da Saúde (CCS)pt_BR
dc.contributor.affiliationNational Hellenic Research Foundation, Institute of Chemical Biologypt_BR
dc.contributor.affiliationUniversidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filhopt_BR
dc.contributor.affiliationAlma Mater Studiorum - University of Bologna, Department of Pharmacy and Biotechnologypt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Medicine, Tropical Medicine Centerpt_BR
dc.contributor.affiliationUniversity of Brasília, Faculty of Health Sciences, Department of Pharmacypt_BR
dc.contributor.affiliationNational Hellenic Research Foundation, Institute of Chemical Biologypt_BR
dc.description.unidadeFaculdade de Medicina (FM)pt_BR
dc.description.unidadeFaculdade de Ciências da Saúde (FS)pt_BR
dc.description.unidadeDepartamento de Farmácia (FS FAR)pt_BR
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